Continuous quinacrine treatment results in the formation of drug-resistant prions.

Quinacrine is a potent antiprion compound in cell culture models of prion disease but has failed to show efficacy in animal bioassays and human clinical trials. Previous studies demonstrated that quinacrine inefficiently penetrates the blood-brain barrier (BBB), which could contribute to its lack of...

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Autores principales: Sina Ghaemmaghami, Misol Ahn, Pierre Lessard, Kurt Giles, Giuseppe Legname, Stephen J DeArmond, Stanley B Prusiner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/fcfbe9ebc1594422855e2fb3b5334f33
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