LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)

The article highlights the importance of the problem of endemic liver trematode infection (opisthorchiasis and clonorchiasis) and the principles of their diagnosis from the perspective of the clinician. Closely related pathogens (Opisthorchis felineus, Opisthorchis viverrini, Clonorchis sinensis) of...

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Autores principales:	O. A. Baykova, N. N. Nikolaeva, E. G. Grishchenko, L. V. Nikolaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	opisthorchiasis clonorchiasis cholangiocarcinoma cholecystolithiasis detection eggs in fecal samples immunological and molecular methods Science Q
Acceso en línea:	https://doaj.org/article/fcfccc4c63bb40ea8a7e7b23c72c5596
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spelling	oai:doaj.org-article:fcfccc4c63bb40ea8a7e7b23c72c55962021-11-23T06:14:36ZLIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)2541-94202587-959610.12737/23825https://doaj.org/article/fcfccc4c63bb40ea8a7e7b23c72c55962016-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/345https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article highlights the importance of the problem of endemic liver trematode infection (opisthorchiasis and clonorchiasis) and the principles of their diagnosis from the perspective of the clinician. Closely related pathogens (Opisthorchis felineus, Opisthorchis viverrini, Clonorchis sinensis) of these diseases are group 1 carcinogens, promoting the development of cholangiocarcinoma of the liver, gallstones, pancreatitis and gastroduodenitis. Specific and early diagnosis of opisthorchiasis in humans is crucial for an appropriate and timely treatment. The basic method of diagnostics in the world clinical practice is a detection of eggs in fecal samples. Once a fecal sample is available, the modified formalin-ether sedimentation technique, the modified thick Kato smear and with Kato - Katz are used. As a single examination does not necessarily provide diagnostic certainty, repeated examinations are necessary to improve diagnostic sensitivity. Immunoassay is considered as an addition to parasitological examination. The EL1SA shows the best performance among the serological tests. Molecular-genetic method (PCR and Loop mediated isothermal amplification (LAMP) is ranked as the most promising. Due to their high specificity, such molecular diagnostic tests are likely to play an increasingly significant role in anthelminthic drug efficacy evaluations, the rigorous monitoring of reinfection patterns, and to investigate changes in the endemic range of the liver flukes.O. A. BaykovaN. N. NikolaevaE. G. GrishchenkoL. V. NikolaevaScientific Сentre for Family Health and Human Reproduction Problemsarticleopisthorchiasisclonorchiasischolangiocarcinomacholecystolithiasisdetection eggs in fecal samplesimmunological and molecular methodsScienceQRUActa Biomedica Scientifica, Vol 1, Iss 6, Pp 182-190 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	opisthorchiasis clonorchiasis cholangiocarcinoma cholecystolithiasis detection eggs in fecal samples immunological and molecular methods Science Q
spellingShingle	opisthorchiasis clonorchiasis cholangiocarcinoma cholecystolithiasis detection eggs in fecal samples immunological and molecular methods Science Q O. A. Baykova N. N. Nikolaeva E. G. Grishchenko L. V. Nikolaeva LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
description	The article highlights the importance of the problem of endemic liver trematode infection (opisthorchiasis and clonorchiasis) and the principles of their diagnosis from the perspective of the clinician. Closely related pathogens (Opisthorchis felineus, Opisthorchis viverrini, Clonorchis sinensis) of these diseases are group 1 carcinogens, promoting the development of cholangiocarcinoma of the liver, gallstones, pancreatitis and gastroduodenitis. Specific and early diagnosis of opisthorchiasis in humans is crucial for an appropriate and timely treatment. The basic method of diagnostics in the world clinical practice is a detection of eggs in fecal samples. Once a fecal sample is available, the modified formalin-ether sedimentation technique, the modified thick Kato smear and with Kato - Katz are used. As a single examination does not necessarily provide diagnostic certainty, repeated examinations are necessary to improve diagnostic sensitivity. Immunoassay is considered as an addition to parasitological examination. The EL1SA shows the best performance among the serological tests. Molecular-genetic method (PCR and Loop mediated isothermal amplification (LAMP) is ranked as the most promising. Due to their high specificity, such molecular diagnostic tests are likely to play an increasingly significant role in anthelminthic drug efficacy evaluations, the rigorous monitoring of reinfection patterns, and to investigate changes in the endemic range of the liver flukes.
format	article
author	O. A. Baykova N. N. Nikolaeva E. G. Grishchenko L. V. Nikolaeva
author_facet	O. A. Baykova N. N. Nikolaeva E. G. Grishchenko L. V. Nikolaeva
author_sort	O. A. Baykova
title	LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
title_short	LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
title_full	LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
title_fullStr	LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
title_full_unstemmed	LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)
title_sort	liver trematode infection - opisthorchiasis and clonorchiasis: actual problems and principles of diagnosis in modern clinical practice (review of literature)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/fcfccc4c63bb40ea8a7e7b23c72c5596
work_keys_str_mv	AT oabaykova livertrematodeinfectionopisthorchiasisandclonorchiasisactualproblemsandprinciplesofdiagnosisinmodernclinicalpracticereviewofliterature AT nnnikolaeva livertrematodeinfectionopisthorchiasisandclonorchiasisactualproblemsandprinciplesofdiagnosisinmodernclinicalpracticereviewofliterature AT eggrishchenko livertrematodeinfectionopisthorchiasisandclonorchiasisactualproblemsandprinciplesofdiagnosisinmodernclinicalpracticereviewofliterature AT lvnikolaeva livertrematodeinfectionopisthorchiasisandclonorchiasisactualproblemsandprinciplesofdiagnosisinmodernclinicalpracticereviewofliterature
_version_	1718417048741085184

LIVER TREMATODE INFECTION - OPISTHORCHIASIS AND CLONORCHIASIS: ACTUAL PROBLEMS AND PRINCIPLES OF DIAGNOSIS IN MODERN CLINICAL PRACTICE (REVIEW OF LITERATURE)

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