E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 sig...

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Autores principales:	Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc775
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spelling	oai:doaj.org-article:fcfe5f0cdf014198b141e4fc270fc7752021-12-02T15:37:07ZE3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP10.1038/ncomms158652041-1723https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc7752017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15865https://doaj.org/toc/2041-1723Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling.Pradeep BistWan Shoo CheongAylwin NgNeha DikshitBae-Hoon KimNiyas Kudukkil PulloorHanif Javanmard KhamenehMatija HedlAvinash R. ShenoyVanniarajan BalamuralidharNajib Bin Abdul MalikMichelle HongAlbert NeutznerKeh-Chuang ChinKoichi S. KobayashiAntonio BertolettiAlessandra MortellaroClara AbrahamJohn D. MacMickingRamnik J. XavierBindu SukumaranNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
description	Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling.
format	article
author	Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran
author_facet	Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran
author_sort	Pradeep Bist
title	E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
title_short	E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
title_full	E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
title_fullStr	E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
title_full_unstemmed	E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
title_sort	e3 ubiquitin ligase znrf4 negatively regulates nod2 signalling and induces tolerance to mdp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc775
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E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

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