Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation

Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation

Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, a...

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Autores principales: Bo Pang, Rijing Liao, Zhijun Tang, Shengjie Guo, Zhuhua Wu, Wen Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fcfe808743254d1d891ebd5421192777
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spelling oai:doaj.org-article:fcfe808743254d1d891ebd54211927772021-12-02T16:53:15ZCaerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation10.1038/s41467-021-23475-42041-1723https://doaj.org/article/fcfe808743254d1d891ebd54211927772021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23475-4https://doaj.org/toc/2041-1723Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, and clarify the process for 2,2’-bipyridine furcation.Bo PangRijing LiaoZhijun TangShengjie GuoZhuhua WuWen LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
description Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, and clarify the process for 2,2’-bipyridine furcation.
format article
author Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
author_facet Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
author_sort Bo Pang
title Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_short Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_full Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_fullStr Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_full_unstemmed Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_sort caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fcfe808743254d1d891ebd5421192777
work_keys_str_mv AT bopang caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT rijingliao caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT zhijuntang caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT shengjieguo caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT zhuhuawu caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT wenliu caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
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