Quantitative analysis of PiB-PET with FreeSurfer ROIs.

In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use ma...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi Su, Gina M D'Angelo, Andrei G Vlassenko, Gongfu Zhou, Abraham Z Snyder, Daniel S Marcus, Tyler M Blazey, Jon J Christensen, Shivangi Vora, John C Morris, Mark A Mintun, Tammie L S Benzinger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd03dee90e324e689d108d36b52c898e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd03dee90e324e689d108d36b52c898e
record_format	dspace
spelling	oai:doaj.org-article:fd03dee90e324e689d108d36b52c898e2021-11-18T08:48:11ZQuantitative analysis of PiB-PET with FreeSurfer ROIs.1932-620310.1371/journal.pone.0073377https://doaj.org/article/fd03dee90e324e689d108d36b52c898e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223109/?tool=EBIhttps://doaj.org/toc/1932-6203In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions.Yi SuGina M D'AngeloAndrei G VlassenkoGongfu ZhouAbraham Z SnyderDaniel S MarcusTyler M BlazeyJon J ChristensenShivangi VoraJohn C MorrisMark A MintunTammie L S BenzingerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e73377 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Su Gina M D'Angelo Andrei G Vlassenko Gongfu Zhou Abraham Z Snyder Daniel S Marcus Tyler M Blazey Jon J Christensen Shivangi Vora John C Morris Mark A Mintun Tammie L S Benzinger Quantitative analysis of PiB-PET with FreeSurfer ROIs.
description	In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions.
format	article
author	Yi Su Gina M D'Angelo Andrei G Vlassenko Gongfu Zhou Abraham Z Snyder Daniel S Marcus Tyler M Blazey Jon J Christensen Shivangi Vora John C Morris Mark A Mintun Tammie L S Benzinger
author_facet	Yi Su Gina M D'Angelo Andrei G Vlassenko Gongfu Zhou Abraham Z Snyder Daniel S Marcus Tyler M Blazey Jon J Christensen Shivangi Vora John C Morris Mark A Mintun Tammie L S Benzinger
author_sort	Yi Su
title	Quantitative analysis of PiB-PET with FreeSurfer ROIs.
title_short	Quantitative analysis of PiB-PET with FreeSurfer ROIs.
title_full	Quantitative analysis of PiB-PET with FreeSurfer ROIs.
title_fullStr	Quantitative analysis of PiB-PET with FreeSurfer ROIs.
title_full_unstemmed	Quantitative analysis of PiB-PET with FreeSurfer ROIs.
title_sort	quantitative analysis of pib-pet with freesurfer rois.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fd03dee90e324e689d108d36b52c898e
work_keys_str_mv	AT yisu quantitativeanalysisofpibpetwithfreesurferrois AT ginamdangelo quantitativeanalysisofpibpetwithfreesurferrois AT andreigvlassenko quantitativeanalysisofpibpetwithfreesurferrois AT gongfuzhou quantitativeanalysisofpibpetwithfreesurferrois AT abrahamzsnyder quantitativeanalysisofpibpetwithfreesurferrois AT danielsmarcus quantitativeanalysisofpibpetwithfreesurferrois AT tylermblazey quantitativeanalysisofpibpetwithfreesurferrois AT jonjchristensen quantitativeanalysisofpibpetwithfreesurferrois AT shivangivora quantitativeanalysisofpibpetwithfreesurferrois AT johncmorris quantitativeanalysisofpibpetwithfreesurferrois AT markamintun quantitativeanalysisofpibpetwithfreesurferrois AT tammielsbenzinger quantitativeanalysisofpibpetwithfreesurferrois
_version_	1718421301351153664

Quantitative analysis of PiB-PET with FreeSurfer ROIs.

Ejemplares similares