The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells

Colon cancer is one of the leading causes of death in the world. The search for effective and minimally invasive methods of treating colon cancer is the aim of modern medicine. Chalcones and their derivatives have shown an anticancer activity. The aim of the study was to evaluate the effect of metho...

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Autores principales:	Joanna Bronikowska, Małgorzata Kłósek, Tomasz Janeczko, Edyta Kostrzewa-Susłow, Zenon P. Czuba
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Colon cancer Chalcone derivatives Cytokines Adhesion molecules Chemoprevention Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fd0416ec96e24ab6b640128e773fdcaa
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spelling	oai:doaj.org-article:fd0416ec96e24ab6b640128e773fdcaa2021-11-18T04:43:37ZThe modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells0753-332210.1016/j.biopha.2021.112428https://doaj.org/article/fd0416ec96e24ab6b640128e773fdcaa2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012142https://doaj.org/toc/0753-3322Colon cancer is one of the leading causes of death in the world. The search for effective and minimally invasive methods of treating colon cancer is the aim of modern medicine. Chalcones and their derivatives have shown an anticancer activity. The aim of the study was to evaluate the effect of methoxy-derivatives of 2’-hydroxychalcones: 2’-hydroxy-3”-methoxychalcone (TJ3), 2’-hydroxy-2”-methoxychalcone (TJ6) and 2’-hydroxy-4”-metoxychalcone (TJ7) at the concentrations of 10 µM and 25 µM on the release of IL-8, MIF, VCAM-1, ICAM-1 by colon cancer SW480 and SW620 cell lines. The cytokines and adhesion molecules were detected using the Bio-Plex Magnetic Luminex Assay and the Bio-Plex Suspension Array System. Our results showed that all tested methoxy-derivatives of 2’-hydroxychalcone compounds significantly reduced ICAM-1 released by SW480 cancer cells. The tested compounds at both concentrations did not significantly affect VCAM-1 released by SW480 and SW620 cancer cell lines. All methoxy-derivatives significantly reduced the concentration of MIF in dose dependent manner on SW480 cells. The TJ3 at the concentration of 25 µM significantly decreased IL-8 secreted by SW480 and SW620 cancer cells. Our results demonstrated that tested methoxy-derivatives of 2’-hydroxychalcones showed modulating effect on colon cancer cells.Joanna BronikowskaMałgorzata KłósekTomasz JaneczkoEdyta Kostrzewa-SusłowZenon P. CzubaElsevierarticleColon cancerChalcone derivativesCytokinesAdhesion moleculesChemopreventionTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112428- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Colon cancer Chalcone derivatives Cytokines Adhesion molecules Chemoprevention Therapeutics. Pharmacology RM1-950
spellingShingle	Colon cancer Chalcone derivatives Cytokines Adhesion molecules Chemoprevention Therapeutics. Pharmacology RM1-950 Joanna Bronikowska Małgorzata Kłósek Tomasz Janeczko Edyta Kostrzewa-Susłow Zenon P. Czuba The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
description	Colon cancer is one of the leading causes of death in the world. The search for effective and minimally invasive methods of treating colon cancer is the aim of modern medicine. Chalcones and their derivatives have shown an anticancer activity. The aim of the study was to evaluate the effect of methoxy-derivatives of 2’-hydroxychalcones: 2’-hydroxy-3”-methoxychalcone (TJ3), 2’-hydroxy-2”-methoxychalcone (TJ6) and 2’-hydroxy-4”-metoxychalcone (TJ7) at the concentrations of 10 µM and 25 µM on the release of IL-8, MIF, VCAM-1, ICAM-1 by colon cancer SW480 and SW620 cell lines. The cytokines and adhesion molecules were detected using the Bio-Plex Magnetic Luminex Assay and the Bio-Plex Suspension Array System. Our results showed that all tested methoxy-derivatives of 2’-hydroxychalcone compounds significantly reduced ICAM-1 released by SW480 cancer cells. The tested compounds at both concentrations did not significantly affect VCAM-1 released by SW480 and SW620 cancer cell lines. All methoxy-derivatives significantly reduced the concentration of MIF in dose dependent manner on SW480 cells. The TJ3 at the concentration of 25 µM significantly decreased IL-8 secreted by SW480 and SW620 cancer cells. Our results demonstrated that tested methoxy-derivatives of 2’-hydroxychalcones showed modulating effect on colon cancer cells.
format	article
author	Joanna Bronikowska Małgorzata Kłósek Tomasz Janeczko Edyta Kostrzewa-Susłow Zenon P. Czuba
author_facet	Joanna Bronikowska Małgorzata Kłósek Tomasz Janeczko Edyta Kostrzewa-Susłow Zenon P. Czuba
author_sort	Joanna Bronikowska
title	The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
title_short	The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
title_full	The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
title_fullStr	The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
title_full_unstemmed	The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells
title_sort	modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of il-8, mif, vcam-1 and icam-1 by colon cancer cells
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/fd0416ec96e24ab6b640128e773fdcaa
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The modulating effect of methoxy-derivatives of 2’-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells

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