Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?

Cystic fibrosis (CF) is an autosomal recessive gene disorder that affects tens of thousands of patients worldwide. Individuals with CF often succumb to progressive lung disease and respiratory failure following recurrent infections with bacteria. Viral infections can also damage the lungs and height...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Robert E. Sealy, Sherri L. Surman, Peter Vogel, Julia L. Hurwitz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cystic fibrosis vitamin A respiratory virus infection mouse model prevention Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fd09b7dfbcfa40d8881115d2b3a53776
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd09b7dfbcfa40d8881115d2b3a53776
record_format	dspace
spelling	oai:doaj.org-article:fd09b7dfbcfa40d8881115d2b3a537762021-11-09T06:24:37ZMight Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?1664-322410.3389/fimmu.2021.704391https://doaj.org/article/fd09b7dfbcfa40d8881115d2b3a537762021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.704391/fullhttps://doaj.org/toc/1664-3224Cystic fibrosis (CF) is an autosomal recessive gene disorder that affects tens of thousands of patients worldwide. Individuals with CF often succumb to progressive lung disease and respiratory failure following recurrent infections with bacteria. Viral infections can also damage the lungs and heighten the CF patient’s susceptibility to bacterial infections and long-term sequelae. Vitamin A is a key nutrient important for immune health and epithelial cell integrity, but there is currently no consensus as to whether vitamin A should be monitored in CF patients. Here we evaluate previous literature and present results from a CF mouse model, showing that oral vitamin A supplements significantly reduce lung lesions that would otherwise persist for 5-6 weeks post-virus exposure. Based on these results, we encourage continued research and suggest that programs for the routine monitoring and regulation of vitamin A levels may help reduce virus-induced lung pathology in CF patients.Robert E. SealySherri L. SurmanPeter VogelJulia L. HurwitzJulia L. HurwitzFrontiers Media S.A.articlecystic fibrosisvitamin Arespiratory virus infectionmouse modelpreventionImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystic fibrosis vitamin A respiratory virus infection mouse model prevention Immunologic diseases. Allergy RC581-607
spellingShingle	cystic fibrosis vitamin A respiratory virus infection mouse model prevention Immunologic diseases. Allergy RC581-607 Robert E. Sealy Sherri L. Surman Peter Vogel Julia L. Hurwitz Julia L. Hurwitz Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
description	Cystic fibrosis (CF) is an autosomal recessive gene disorder that affects tens of thousands of patients worldwide. Individuals with CF often succumb to progressive lung disease and respiratory failure following recurrent infections with bacteria. Viral infections can also damage the lungs and heighten the CF patient’s susceptibility to bacterial infections and long-term sequelae. Vitamin A is a key nutrient important for immune health and epithelial cell integrity, but there is currently no consensus as to whether vitamin A should be monitored in CF patients. Here we evaluate previous literature and present results from a CF mouse model, showing that oral vitamin A supplements significantly reduce lung lesions that would otherwise persist for 5-6 weeks post-virus exposure. Based on these results, we encourage continued research and suggest that programs for the routine monitoring and regulation of vitamin A levels may help reduce virus-induced lung pathology in CF patients.
format	article
author	Robert E. Sealy Sherri L. Surman Peter Vogel Julia L. Hurwitz Julia L. Hurwitz
author_facet	Robert E. Sealy Sherri L. Surman Peter Vogel Julia L. Hurwitz Julia L. Hurwitz
author_sort	Robert E. Sealy
title	Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
title_short	Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
title_full	Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
title_fullStr	Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
title_full_unstemmed	Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?
title_sort	might routine vitamin a monitoring in cystic fibrosis patients reduce virus-mediated lung pathology?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fd09b7dfbcfa40d8881115d2b3a53776
work_keys_str_mv	AT robertesealy mightroutinevitaminamonitoringincysticfibrosispatientsreducevirusmediatedlungpathology AT sherrilsurman mightroutinevitaminamonitoringincysticfibrosispatientsreducevirusmediatedlungpathology AT petervogel mightroutinevitaminamonitoringincysticfibrosispatientsreducevirusmediatedlungpathology AT julialhurwitz mightroutinevitaminamonitoringincysticfibrosispatientsreducevirusmediatedlungpathology AT julialhurwitz mightroutinevitaminamonitoringincysticfibrosispatientsreducevirusmediatedlungpathology
_version_	1718441352735227904

Might Routine Vitamin A Monitoring in Cystic Fibrosis Patients Reduce Virus-Mediated Lung Pathology?

Ejemplares similares