The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum...

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Autores principales:	Xiaoling Zhuge, Hao Zhou, Liming Chen, Hui Chen, Xiao Chen, Chuangen Guo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Intraductal papillary mucinous neoplasms Ferritin Malignancy Invasive carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fd09f5a60abb4a11bf8930cdcb0772c9
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spelling	oai:doaj.org-article:fd09f5a60abb4a11bf8930cdcb0772c92021-11-21T12:30:21ZThe association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms10.1186/s12885-021-08986-z1471-2407https://doaj.org/article/fd09f5a60abb4a11bf8930cdcb0772c92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08986-zhttps://doaj.org/toc/1471-2407Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p < 0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs.Xiaoling ZhugeHao ZhouLiming ChenHui ChenXiao ChenChuangen GuoBMCarticleIntraductal papillary mucinous neoplasmsFerritinMalignancyInvasive carcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intraductal papillary mucinous neoplasms Ferritin Malignancy Invasive carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Intraductal papillary mucinous neoplasms Ferritin Malignancy Invasive carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
description	Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p < 0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs.
format	article
author	Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo
author_facet	Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo
author_sort	Xiaoling Zhuge
title	The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
title_short	The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
title_full	The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
title_fullStr	The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
title_full_unstemmed	The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
title_sort	association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fd09f5a60abb4a11bf8930cdcb0772c9
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The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

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