Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro

Abstract Surfactants are important components of oral care products. Sodium dodecyl sulfate (SDS) is the most common because of its foaming properties, taste and low cost. However, the use of ionic surfactants, especially SDS, is related to several oral mucosa conditions. Thus, there is a high inter...

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Autores principales:	Hannah Boyd, Juan F. Gonzalez-Martinez, Rebecca J. L. Welbourn, Kun Ma, Peixun Li, Philipp Gutfreund, Alexey Klechikov, Thomas Arnebrant, Robert Barker, Javier Sotres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd0a45a099a5496fb630d34b8763aa4e
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spelling	oai:doaj.org-article:fd0a45a099a5496fb630d34b8763aa4e2021-12-02T18:02:44ZEffect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro10.1038/s41598-021-92505-42045-2322https://doaj.org/article/fd0a45a099a5496fb630d34b8763aa4e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92505-4https://doaj.org/toc/2045-2322Abstract Surfactants are important components of oral care products. Sodium dodecyl sulfate (SDS) is the most common because of its foaming properties, taste and low cost. However, the use of ionic surfactants, especially SDS, is related to several oral mucosa conditions. Thus, there is a high interest in using non-ionic and amphoteric surfactants as they are less irritant. To better understand the performance of these surfactants in oral care products, we investigated their interaction with salivary pellicles i.e., the proteinaceous films that cover surfaces exposed to saliva. Specifically, we focused on pentaethylene glycol monododecyl ether (C12E5) and cocamidopropyl betaine (CAPB) as model nonionic and amphoteric surfactants respectively, and investigated their interaction with reconstituted salivary pellicles with various surface techniques: Quartz Crystal Microbalance with Dissipation, Ellipsometry, Force Spectroscopy and Neutron Reflectometry. Both C12E5 and CAPB were gentler on pellicles than SDS, removing a lower amount. However, their interaction with pellicles differed. Our work indicates that CAPB would mainly interact with the mucin components of pellicles, leading to collapse and dehydration. In contrast, exposure to C12E5 had a minimal effect on the pellicles, mainly resulting in the replacement/solubilisation of some of the components anchoring pellicles to their substrate.Hannah BoydJuan F. Gonzalez-MartinezRebecca J. L. WelbournKun MaPeixun LiPhilipp GutfreundAlexey KlechikovThomas ArnebrantRobert BarkerJavier SotresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hannah Boyd Juan F. Gonzalez-Martinez Rebecca J. L. Welbourn Kun Ma Peixun Li Philipp Gutfreund Alexey Klechikov Thomas Arnebrant Robert Barker Javier Sotres Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
description	Abstract Surfactants are important components of oral care products. Sodium dodecyl sulfate (SDS) is the most common because of its foaming properties, taste and low cost. However, the use of ionic surfactants, especially SDS, is related to several oral mucosa conditions. Thus, there is a high interest in using non-ionic and amphoteric surfactants as they are less irritant. To better understand the performance of these surfactants in oral care products, we investigated their interaction with salivary pellicles i.e., the proteinaceous films that cover surfaces exposed to saliva. Specifically, we focused on pentaethylene glycol monododecyl ether (C12E5) and cocamidopropyl betaine (CAPB) as model nonionic and amphoteric surfactants respectively, and investigated their interaction with reconstituted salivary pellicles with various surface techniques: Quartz Crystal Microbalance with Dissipation, Ellipsometry, Force Spectroscopy and Neutron Reflectometry. Both C12E5 and CAPB were gentler on pellicles than SDS, removing a lower amount. However, their interaction with pellicles differed. Our work indicates that CAPB would mainly interact with the mucin components of pellicles, leading to collapse and dehydration. In contrast, exposure to C12E5 had a minimal effect on the pellicles, mainly resulting in the replacement/solubilisation of some of the components anchoring pellicles to their substrate.
format	article
author	Hannah Boyd Juan F. Gonzalez-Martinez Rebecca J. L. Welbourn Kun Ma Peixun Li Philipp Gutfreund Alexey Klechikov Thomas Arnebrant Robert Barker Javier Sotres
author_facet	Hannah Boyd Juan F. Gonzalez-Martinez Rebecca J. L. Welbourn Kun Ma Peixun Li Philipp Gutfreund Alexey Klechikov Thomas Arnebrant Robert Barker Javier Sotres
author_sort	Hannah Boyd
title	Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
title_short	Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
title_full	Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
title_fullStr	Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
title_full_unstemmed	Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
title_sort	effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd0a45a099a5496fb630d34b8763aa4e
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Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro

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