Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study

Chao Li,1–3,* Jianbo Lai,1,4,5,* Tingting Huang,2 Yuqing Han,2 Yanli Du,2 Yi Xu,1,4,5 Shaohua Hu1,4,51Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of China; 2Department of Clinical Medicine, Zhejia...

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Autores principales:	Li C, Lai J, Huang T, Han Y, Du Y, Xu Y, Hu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	thyroid function bipolar disorder quetiapine mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fd1125e4f43048bc98d0b7a488db0b39
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spelling	oai:doaj.org-article:fd1125e4f43048bc98d0b7a488db0b392021-12-02T05:39:41ZThyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study1178-2021https://doaj.org/article/fd1125e4f43048bc98d0b7a488db0b392019-08-01T00:00:00Zhttps://www.dovepress.com/thyroid-functions-in-patients-with-bipolar-disorder-and-the-impact-of--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chao Li,1–3,* Jianbo Lai,1,4,5,* Tingting Huang,2 Yuqing Han,2 Yanli Du,2 Yi Xu,1,4,5 Shaohua Hu1,4,51Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of China; 2Department of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of China; 3Department of Psychiatry, Ningbo Psychiatric Hospital of Zhejiang Province, Ningbo 315000, People’s Republic of China; 4The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, People’s Republic of China; 5Brain Research Institute of Zhejiang University, Hangzhou 310003, People’s Republic of China*These authors contributed equally to this workObjective: Previous studies have demonstrated a potentially close relationship between mood disorders and thyroid abnormalities. The aims of this study are to investigate: 1) whether significant differences of thyroid profiles exist between manic and depressive episodes in patients with bipolar disorder (BD); 2) the impact of quetiapine monotherapy on thyroid functions in depressed BD patients.Methods: In this retrospective naturalistic study, we reviewed patients’ information based on an electronic medical system from January 2015 to April 2019. Patients with a discharge diagnosis of BD, a current depressive or manic episode, were screened. All depressed BD patients were treated with quetiapine monotherapy for at least one month. For all patients enrolled, the demographic, clinical data and thyroid functions were recorded. The differences between thyroid profiles including total thyroxine (TT4), total triiodothyronine (TT3), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) between patients with different episodes were analyzed. In addition, the change of thyroid functions before and after one-month or three-month quetiapine treatment in depressed BD patients was also analyzed.Results: Totally, 28 patients with a manic episode and 58 patients with a depressive episode were enrolled. No significant differences in thyroid profiles were found in patients with different mood episodes. After one-month quetiapine treatment, serum levels of TT4, FT4 and FT3 were significantly reduced (P<0.05), TSH was increased (P=0.015), while TT3 was not significantly changed (P=0.425). After three-month quetiapine treatment, serum levels of TT4, TT3, FT4 and FT3 were significantly reduced (P<0.05), except TSH (P=0.990).Conclusion: These findings indicate that thyroid functions were not significantly fluctuated between depressive and manic episodes in BD patients. Nonetheless, quetiapine treatment may disturb the thyroid system and needs close monitoring.Keywords: thyroid function, bipolar disorder, quetiapine, mania  Li CLai JHuang THan YDu YXu YHu SDove Medical Pressarticlethyroid functionbipolar disorderquetiapinemaniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2285-2290 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid function bipolar disorder quetiapine mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	thyroid function bipolar disorder quetiapine mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li C Lai J Huang T Han Y Du Y Xu Y Hu S Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
description	Chao Li,1–3,* Jianbo Lai,1,4,5,* Tingting Huang,2 Yuqing Han,2 Yanli Du,2 Yi Xu,1,4,5 Shaohua Hu1,4,51Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of China; 2Department of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou 310003, People’s Republic of China; 3Department of Psychiatry, Ningbo Psychiatric Hospital of Zhejiang Province, Ningbo 315000, People’s Republic of China; 4The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, People’s Republic of China; 5Brain Research Institute of Zhejiang University, Hangzhou 310003, People’s Republic of China*These authors contributed equally to this workObjective: Previous studies have demonstrated a potentially close relationship between mood disorders and thyroid abnormalities. The aims of this study are to investigate: 1) whether significant differences of thyroid profiles exist between manic and depressive episodes in patients with bipolar disorder (BD); 2) the impact of quetiapine monotherapy on thyroid functions in depressed BD patients.Methods: In this retrospective naturalistic study, we reviewed patients’ information based on an electronic medical system from January 2015 to April 2019. Patients with a discharge diagnosis of BD, a current depressive or manic episode, were screened. All depressed BD patients were treated with quetiapine monotherapy for at least one month. For all patients enrolled, the demographic, clinical data and thyroid functions were recorded. The differences between thyroid profiles including total thyroxine (TT4), total triiodothyronine (TT3), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) between patients with different episodes were analyzed. In addition, the change of thyroid functions before and after one-month or three-month quetiapine treatment in depressed BD patients was also analyzed.Results: Totally, 28 patients with a manic episode and 58 patients with a depressive episode were enrolled. No significant differences in thyroid profiles were found in patients with different mood episodes. After one-month quetiapine treatment, serum levels of TT4, FT4 and FT3 were significantly reduced (P<0.05), TSH was increased (P=0.015), while TT3 was not significantly changed (P=0.425). After three-month quetiapine treatment, serum levels of TT4, TT3, FT4 and FT3 were significantly reduced (P<0.05), except TSH (P=0.990).Conclusion: These findings indicate that thyroid functions were not significantly fluctuated between depressive and manic episodes in BD patients. Nonetheless, quetiapine treatment may disturb the thyroid system and needs close monitoring.Keywords: thyroid function, bipolar disorder, quetiapine, mania
format	article
author	Li C Lai J Huang T Han Y Du Y Xu Y Hu S
author_facet	Li C Lai J Huang T Han Y Du Y Xu Y Hu S
author_sort	Li C
title	Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
title_short	Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
title_full	Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
title_fullStr	Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
title_full_unstemmed	Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
title_sort	thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fd1125e4f43048bc98d0b7a488db0b39
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Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study

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