Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels

Background: The purpose of this study was to identify predictors and preventative treatments for post-stroke epilepsy (PSE). Methodology: Eighty-four patients who had suffered a cerebrovascular insult (within 72 hours) were recruited and divided into two groups: an EP group (patients with seizures a...

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Autores principales:	Xie Wen-Jing, Dong Ming, Liu Qun, Meng Hong-Mei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	cerebrovascular diseases epilepsy glutamate γ-aminobutyric acid (gaba) calcium high performance liquid chromatography (hplc) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/fd119583846d4a60a9588893a1b729c9
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spelling	oai:doaj.org-article:fd119583846d4a60a9588893a1b729c92021-12-05T14:11:04ZEarly predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels2081-693610.1515/tnsci-2016-0001https://doaj.org/article/fd119583846d4a60a9588893a1b729c92016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0001https://doaj.org/toc/2081-6936Background: The purpose of this study was to identify predictors and preventative treatments for post-stroke epilepsy (PSE). Methodology: Eighty-four patients who had suffered a cerebrovascular insult (within 72 hours) were recruited and divided into two groups: an EP group (patients with seizures after stroke) and a NEP group (patients without seizures after stroke). The NEP group was then subdivided into three groups: a control group, a GABA (γ-aminobutiric acid) group (received GABA orally), and a CCB group (received calcium channel blocker nimodipine orally). Patient groups were compared by gender, age, past medical history, stroke type, number of lesions, and position and stroke severity (using Scandinavian stroke scale, SSS). Forearm venous blood was sampled, and high performance liquid chromatography (HPLC) was used to measure plasma levels of neurotransmitters and Ca2+. Patients then received 14 days of drug intervention. One month after drug withdrawal, GABA, glutamate (Glu) and Ca2+ concentrations in plasma were measured again. Results: The number of previous strokes, size of infarction, presence of multiple lesions, localization to the cortex, and SSS were statistically significant between the two groups (P < 0.05). In the EP group, the Glu concentration was greater and the Ca2+ concentration was lower than in the NEP group (P < 0.05). The results obtained after 1 month of therapy showed a reduction in Glu levels and an increase in GABA levels in the GABA group relative to the control NEP group (P < 0.05), while the CCB group showed a decrease in the concentration of Glu and an increase in the concentrations of GABA and Ca2+ relative to the NEP control group (P < 0.05). Conclusions: We identified susceptibility factors for PSE and demonstrated that GABA and calcium antagonists may have a therapeutic use in the early prevention of PSE.Xie Wen-JingDong MingLiu QunMeng Hong-MeiDe Gruyterarticlecerebrovascular diseasesepilepsyglutamateγ-aminobutyric acid (gaba)calciumhigh performance liquid chromatography (hplc)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 1-5 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebrovascular diseases epilepsy glutamate γ-aminobutyric acid (gaba) calcium high performance liquid chromatography (hplc) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cerebrovascular diseases epilepsy glutamate γ-aminobutyric acid (gaba) calcium high performance liquid chromatography (hplc) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xie Wen-Jing Dong Ming Liu Qun Meng Hong-Mei Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
description	Background: The purpose of this study was to identify predictors and preventative treatments for post-stroke epilepsy (PSE). Methodology: Eighty-four patients who had suffered a cerebrovascular insult (within 72 hours) were recruited and divided into two groups: an EP group (patients with seizures after stroke) and a NEP group (patients without seizures after stroke). The NEP group was then subdivided into three groups: a control group, a GABA (γ-aminobutiric acid) group (received GABA orally), and a CCB group (received calcium channel blocker nimodipine orally). Patient groups were compared by gender, age, past medical history, stroke type, number of lesions, and position and stroke severity (using Scandinavian stroke scale, SSS). Forearm venous blood was sampled, and high performance liquid chromatography (HPLC) was used to measure plasma levels of neurotransmitters and Ca2+. Patients then received 14 days of drug intervention. One month after drug withdrawal, GABA, glutamate (Glu) and Ca2+ concentrations in plasma were measured again. Results: The number of previous strokes, size of infarction, presence of multiple lesions, localization to the cortex, and SSS were statistically significant between the two groups (P < 0.05). In the EP group, the Glu concentration was greater and the Ca2+ concentration was lower than in the NEP group (P < 0.05). The results obtained after 1 month of therapy showed a reduction in Glu levels and an increase in GABA levels in the GABA group relative to the control NEP group (P < 0.05), while the CCB group showed a decrease in the concentration of Glu and an increase in the concentrations of GABA and Ca2+ relative to the NEP control group (P < 0.05). Conclusions: We identified susceptibility factors for PSE and demonstrated that GABA and calcium antagonists may have a therapeutic use in the early prevention of PSE.
format	article
author	Xie Wen-Jing Dong Ming Liu Qun Meng Hong-Mei
author_facet	Xie Wen-Jing Dong Ming Liu Qun Meng Hong-Mei
author_sort	Xie Wen-Jing
title	Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
title_short	Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
title_full	Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
title_fullStr	Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
title_full_unstemmed	Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
title_sort	early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/fd119583846d4a60a9588893a1b729c9
work_keys_str_mv	AT xiewenjing earlypredictorsandpreventionforpoststrokeepilepsychangesinneurotransmitterlevels AT dongming earlypredictorsandpreventionforpoststrokeepilepsychangesinneurotransmitterlevels AT liuqun earlypredictorsandpreventionforpoststrokeepilepsychangesinneurotransmitterlevels AT menghongmei earlypredictorsandpreventionforpoststrokeepilepsychangesinneurotransmitterlevels
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Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels

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