SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate (C1P) availability in podocytes, and that C1P su...

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Autores principales:	A. Mitrofanova, S. K. Mallela, G. M. Ducasa, T. H. Yoo, E. Rosenfeld-Gur, I. D. Zelnik, J. Molina, J. Varona Santos, M. Ge, A. Sloan, J. J. Kim, C. Pedigo, J. Bryn, I. Volosenco, C. Faul, Y. H. Zeidan, C. Garcia Hernandez, A. J. Mendez, I. Leibiger, G. W. Burke, A. H. Futerman, L. Barisoni, Y. Ishimoto, R. Inagi, S. Merscher, A. Fornoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd12f6a07e0c479dbcdbe26fe66e7a72
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spelling	oai:doaj.org-article:fd12f6a07e0c479dbcdbe26fe66e7a722021-12-02T15:35:27ZSMPDL3b modulates insulin receptor signaling in diabetic kidney disease10.1038/s41467-019-10584-42041-1723https://doaj.org/article/fd12f6a07e0c479dbcdbe26fe66e7a722019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10584-4https://doaj.org/toc/2041-1723Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate (C1P) availability in podocytes, and that C1P supplementation protects mice from diabetic kidney disease.A. MitrofanovaS. K. MallelaG. M. DucasaT. H. YooE. Rosenfeld-GurI. D. ZelnikJ. MolinaJ. Varona SantosM. GeA. SloanJ. J. KimC. PedigoJ. BrynI. VolosencoC. FaulY. H. ZeidanC. Garcia HernandezA. J. MendezI. LeibigerG. W. BurkeA. H. FutermanL. BarisoniY. IshimotoR. InagiS. MerscherA. FornoniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Mitrofanova S. K. Mallela G. M. Ducasa T. H. Yoo E. Rosenfeld-Gur I. D. Zelnik J. Molina J. Varona Santos M. Ge A. Sloan J. J. Kim C. Pedigo J. Bryn I. Volosenco C. Faul Y. H. Zeidan C. Garcia Hernandez A. J. Mendez I. Leibiger G. W. Burke A. H. Futerman L. Barisoni Y. Ishimoto R. Inagi S. Merscher A. Fornoni SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
description	Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate (C1P) availability in podocytes, and that C1P supplementation protects mice from diabetic kidney disease.
format	article
author	A. Mitrofanova S. K. Mallela G. M. Ducasa T. H. Yoo E. Rosenfeld-Gur I. D. Zelnik J. Molina J. Varona Santos M. Ge A. Sloan J. J. Kim C. Pedigo J. Bryn I. Volosenco C. Faul Y. H. Zeidan C. Garcia Hernandez A. J. Mendez I. Leibiger G. W. Burke A. H. Futerman L. Barisoni Y. Ishimoto R. Inagi S. Merscher A. Fornoni
author_facet	A. Mitrofanova S. K. Mallela G. M. Ducasa T. H. Yoo E. Rosenfeld-Gur I. D. Zelnik J. Molina J. Varona Santos M. Ge A. Sloan J. J. Kim C. Pedigo J. Bryn I. Volosenco C. Faul Y. H. Zeidan C. Garcia Hernandez A. J. Mendez I. Leibiger G. W. Burke A. H. Futerman L. Barisoni Y. Ishimoto R. Inagi S. Merscher A. Fornoni
author_sort	A. Mitrofanova
title	SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
title_short	SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
title_full	SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
title_fullStr	SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
title_full_unstemmed	SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
title_sort	smpdl3b modulates insulin receptor signaling in diabetic kidney disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fd12f6a07e0c479dbcdbe26fe66e7a72
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SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

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