Feedback within the inter-cellular communication and tumorigenesis in carcinomas.

The classical somatic mutation theory (SMT) of carcinogenesis and metastasis postulates that malignant transformation occurs in cells that accumulate a sufficient amount of mutations in the appropriate oncogenes and/or tumor suppressor genes. These mutations result in cell-autonomous activation of t...

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Autores principales:	Felix Rückert, Robert Grützmann, Christian Pilarsky
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd12fab9d40c4ffa82e096110de5f0f4
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id	oai:doaj.org-article:fd12fab9d40c4ffa82e096110de5f0f4
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spelling	oai:doaj.org-article:fd12fab9d40c4ffa82e096110de5f0f42021-11-18T07:18:23ZFeedback within the inter-cellular communication and tumorigenesis in carcinomas.1932-620310.1371/journal.pone.0036719https://doaj.org/article/fd12fab9d40c4ffa82e096110de5f0f42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22615799/?tool=EBIhttps://doaj.org/toc/1932-6203The classical somatic mutation theory (SMT) of carcinogenesis and metastasis postulates that malignant transformation occurs in cells that accumulate a sufficient amount of mutations in the appropriate oncogenes and/or tumor suppressor genes. These mutations result in cell-autonomous activation of the mutated cell and a growth advantage relative to neighboring cells. However, the SMT cannot completely explain many characteristics of carcinomas. Contrary to the cell-centered view of the SMT with respect to carcinogenesis, recent research has revealed evidence that the tumor microenvironment plays a role in carcinogenesis as well. In this review, we present a new model that accommodates the role of the tumor microenvironment in carcinogenesis and complements the classical SMT. Our "feedback" model emphasizes the role of an altered spatiotemporal communication between epithelial and stromal cells during carcinogenesis: a dysfunctional intracellular signaling in tumorigenic epithelial cells leads to inappropriate cellular responses to stimuli from associated stromal or inflammatory cells. Thus, a positive feedback loop of the information flow between parenchymal and stromal cells results. This constant communication between the stromal cells and the tumor cells causes a perpetually activated state of tumor cells analogous to resonance disaster.Felix RückertRobert GrützmannChristian PilarskyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36719 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felix Rückert Robert Grützmann Christian Pilarsky Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
description	The classical somatic mutation theory (SMT) of carcinogenesis and metastasis postulates that malignant transformation occurs in cells that accumulate a sufficient amount of mutations in the appropriate oncogenes and/or tumor suppressor genes. These mutations result in cell-autonomous activation of the mutated cell and a growth advantage relative to neighboring cells. However, the SMT cannot completely explain many characteristics of carcinomas. Contrary to the cell-centered view of the SMT with respect to carcinogenesis, recent research has revealed evidence that the tumor microenvironment plays a role in carcinogenesis as well. In this review, we present a new model that accommodates the role of the tumor microenvironment in carcinogenesis and complements the classical SMT. Our "feedback" model emphasizes the role of an altered spatiotemporal communication between epithelial and stromal cells during carcinogenesis: a dysfunctional intracellular signaling in tumorigenic epithelial cells leads to inappropriate cellular responses to stimuli from associated stromal or inflammatory cells. Thus, a positive feedback loop of the information flow between parenchymal and stromal cells results. This constant communication between the stromal cells and the tumor cells causes a perpetually activated state of tumor cells analogous to resonance disaster.
format	article
author	Felix Rückert Robert Grützmann Christian Pilarsky
author_facet	Felix Rückert Robert Grützmann Christian Pilarsky
author_sort	Felix Rückert
title	Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
title_short	Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
title_full	Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
title_fullStr	Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
title_full_unstemmed	Feedback within the inter-cellular communication and tumorigenesis in carcinomas.
title_sort	feedback within the inter-cellular communication and tumorigenesis in carcinomas.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fd12fab9d40c4ffa82e096110de5f0f4
work_keys_str_mv	AT felixruckert feedbackwithintheintercellularcommunicationandtumorigenesisincarcinomas AT robertgrutzmann feedbackwithintheintercellularcommunicationandtumorigenesisincarcinomas AT christianpilarsky feedbackwithintheintercellularcommunicationandtumorigenesisincarcinomas
_version_	1718423703090364416

Feedback within the inter-cellular communication and tumorigenesis in carcinomas.

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