A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure

Abstract We aim to determine the impact of an artificial liver support system (ALSS) treatment before liver transplantation (LT), and identify the prognostic factors and evaluate the predictive values of the current commonly used ACLF prognostic models for short-term prognosis after LT. Data from 16...

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Autores principales:	Peng Li, Xi Liang, Shan Xu, Ye Xiong, Jianrong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd132923006c49429ed1d398d089369a
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spelling	oai:doaj.org-article:fd132923006c49429ed1d398d089369a2021-12-02T10:44:08ZA non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure10.1038/s41598-021-82719-x2045-2322https://doaj.org/article/fd132923006c49429ed1d398d089369a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82719-xhttps://doaj.org/toc/2045-2322Abstract We aim to determine the impact of an artificial liver support system (ALSS) treatment before liver transplantation (LT), and identify the prognostic factors and evaluate the predictive values of the current commonly used ACLF prognostic models for short-term prognosis after LT. Data from 166 patients who underwent LT with acute-on-chronic liver failure (ACLF) were retrospectively collected from January 2011 to December 2018 from the First Affiliated Hospital of Zhejiang University School of Medicine. Patients were divided into two groups depending on whether they received ALSS treatment pre-LT. In the observation group, liver function tests and prognostic scores were significantly lower after ALSS treatment, and the waiting time for a donor liver was significantly longer than that of the control group. Both intraoperative blood loss and period of postoperative ICU care were significantly lower; however, there were no significant differences between groups in terms of total postoperative hospital stays. Postoperative 4-week and 12-week survival rates in the observation group were significantly higher than those of the control group. Similar trends were also observed at 48 and 96 weeks, however, without significant difference. Multivariate Cox regression analysis of the risk factors related to prognosis showed that preoperative ALSS treatment, neutrophil–lymphocyte ratio, and intraoperative blood loss were independent predicting factors for 4-week survival rate after transplantation. ALSS treatment combined with LT in patients with HBV-related ACLF improved short-term survival. ALSS treatment pre-LT is an independent protective factor affecting the 4-week survival rate after LT.Peng LiXi LiangShan XuYe XiongJianrong HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peng Li Xi Liang Shan Xu Ye Xiong Jianrong Huang A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
description	Abstract We aim to determine the impact of an artificial liver support system (ALSS) treatment before liver transplantation (LT), and identify the prognostic factors and evaluate the predictive values of the current commonly used ACLF prognostic models for short-term prognosis after LT. Data from 166 patients who underwent LT with acute-on-chronic liver failure (ACLF) were retrospectively collected from January 2011 to December 2018 from the First Affiliated Hospital of Zhejiang University School of Medicine. Patients were divided into two groups depending on whether they received ALSS treatment pre-LT. In the observation group, liver function tests and prognostic scores were significantly lower after ALSS treatment, and the waiting time for a donor liver was significantly longer than that of the control group. Both intraoperative blood loss and period of postoperative ICU care were significantly lower; however, there were no significant differences between groups in terms of total postoperative hospital stays. Postoperative 4-week and 12-week survival rates in the observation group were significantly higher than those of the control group. Similar trends were also observed at 48 and 96 weeks, however, without significant difference. Multivariate Cox regression analysis of the risk factors related to prognosis showed that preoperative ALSS treatment, neutrophil–lymphocyte ratio, and intraoperative blood loss were independent predicting factors for 4-week survival rate after transplantation. ALSS treatment combined with LT in patients with HBV-related ACLF improved short-term survival. ALSS treatment pre-LT is an independent protective factor affecting the 4-week survival rate after LT.
format	article
author	Peng Li Xi Liang Shan Xu Ye Xiong Jianrong Huang
author_facet	Peng Li Xi Liang Shan Xu Ye Xiong Jianrong Huang
author_sort	Peng Li
title	A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
title_short	A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
title_full	A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
title_fullStr	A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
title_full_unstemmed	A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure
title_sort	non-bioartificial liver support system combined with transplantation in hbv-related acute-on-chronic liver failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd132923006c49429ed1d398d089369a
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A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure

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