Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis

Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis

Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet-induced obesity and insulin resistance due to...

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Autores principales: Sandip Mukherjee, Molee Chakraborty, Barbara Ulmasov, Kyle McCommis, Jinsong Zhang, Danielle Carpenter, Eliwaza Naomi Msengi, Jake Haubner, Chun Guo, Daniel P. Pike, Sarbani Ghoshal, David A. Ford, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
IP6K1
NAFLD/NASH
Liver
Metabolism
Hyperglycemia
O-GlcNAcylation
Internal medicine
RC31-1245
Acceso en línea:https://doaj.org/article/fd13f5e8e9714681819f553c2658c06f
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