Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.

The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of breast cancer are poorly understood. In this stu...

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Autores principales:	Li Li, Fenglong Zhao, Juan Lu, Tingting Li, Hong Yang, Chunhui Wu, Yiyao Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd13f9a0dc2a4fa4af65a642294d5cc3
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spelling	oai:doaj.org-article:fd13f9a0dc2a4fa4af65a642294d5cc32021-11-18T08:21:39ZNotch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.1932-620310.1371/journal.pone.0095912https://doaj.org/article/fd13f9a0dc2a4fa4af65a642294d5cc32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24760075/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of breast cancer are poorly understood. In this study, using multiple cellular and molecular approaches, we demonstrated that activation of Notch-1 signaling pathway promoted the malignant behaviors of MDA-MB-231 cells such as increased cell proliferation, colony formation, adhesion, migration, and invasion, and inhibited apoptosis; whereas deactivation of this signaling pathway led to the reversal of the aforementioned malignant cellular behaviors. Furthermore, we found that activation of Notch-1 signaling pathway triggered the activation of NF-κB signaling pathway and up-regulated the expression of NF-κB target genes including MMP-2/-9, VEGF, Survivin, Bcl-xL, and Cyclin D1. These results suggest that Notch-1 signaling pathway play important roles in promoting the malignant phenotype of breast cancer, which may be mediated partly through the activation of NF-κB signaling pathway. Our results further suggest that targeting Notch-1 signaling pathway may become a newer approach to halt the progression of breast cancer.Li LiFenglong ZhaoJuan LuTingting LiHong YangChunhui WuYiyao LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95912 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Li Fenglong Zhao Juan Lu Tingting Li Hong Yang Chunhui Wu Yiyao Liu Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
description	The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of breast cancer are poorly understood. In this study, using multiple cellular and molecular approaches, we demonstrated that activation of Notch-1 signaling pathway promoted the malignant behaviors of MDA-MB-231 cells such as increased cell proliferation, colony formation, adhesion, migration, and invasion, and inhibited apoptosis; whereas deactivation of this signaling pathway led to the reversal of the aforementioned malignant cellular behaviors. Furthermore, we found that activation of Notch-1 signaling pathway triggered the activation of NF-κB signaling pathway and up-regulated the expression of NF-κB target genes including MMP-2/-9, VEGF, Survivin, Bcl-xL, and Cyclin D1. These results suggest that Notch-1 signaling pathway play important roles in promoting the malignant phenotype of breast cancer, which may be mediated partly through the activation of NF-κB signaling pathway. Our results further suggest that targeting Notch-1 signaling pathway may become a newer approach to halt the progression of breast cancer.
format	article
author	Li Li Fenglong Zhao Juan Lu Tingting Li Hong Yang Chunhui Wu Yiyao Liu
author_facet	Li Li Fenglong Zhao Juan Lu Tingting Li Hong Yang Chunhui Wu Yiyao Liu
author_sort	Li Li
title	Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
title_short	Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
title_full	Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
title_fullStr	Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
title_full_unstemmed	Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
title_sort	notch-1 signaling promotes the malignant features of human breast cancer through nf-κb activation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fd13f9a0dc2a4fa4af65a642294d5cc3
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Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.

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