Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm

Abstract Idiopathic blepharospasm shows a female predominance in prevalence, whether there are sex-related differences in distributions of nonmotor symptoms (NMSs) and predictors of quality of life are unknown. Four hundred and twenty-five patients with idiopathic blepharospasm were consecutively re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Yang, Lingyu Zhang, Yanbing Hou, Qianqian Wei, Ruwei Ou, Junyu Lin, Wei Song, Bei Cao, Huifang Shang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd1819d6f100487aa6ba2e9e5fa6c099
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd1819d6f100487aa6ba2e9e5fa6c099
record_format	dspace
spelling	oai:doaj.org-article:fd1819d6f100487aa6ba2e9e5fa6c0992021-12-02T17:19:17ZSex related differences in nonmotor symptoms of patients with idiopathic blepharospasm10.1038/s41598-021-97289-12045-2322https://doaj.org/article/fd1819d6f100487aa6ba2e9e5fa6c0992021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97289-1https://doaj.org/toc/2045-2322Abstract Idiopathic blepharospasm shows a female predominance in prevalence, whether there are sex-related differences in distributions of nonmotor symptoms (NMSs) and predictors of quality of life are unknown. Four hundred and twenty-five patients with idiopathic blepharospasm were consecutively recruited, and underwent assessments including dystonia severity, mood disturbances, sleep disturbances, cognition, ocular symptoms, and quality of life. Frequencies and distributions of NMSs, and predictors of quality of life in female and male patients were investigated. NMSs existed in majority of male (94.0%) and female (95.8%) patients. The frequencies of depression, cognition dysfunction, and poor sleep quality were higher in female patients, while the frequency of excessive daytime sleepiness was higher in male patients. More female (79.5%) patients had multiple NMS domains affected than male (70.1%) patients (p = 0.040). Quality of life was associated with depression, anxiety and motor severity for female patients (adjusted R2 = 0.367, p < 0.001), while associated with depression, excessive daytime sleepiness and motor severity for male patients (adjusted R2 = 0.430, p < 0.001). The highly prevalent coexistence of multiple NMSs found in patients with blepharospasm support that blepharospasm is a network disorder. The sex-related differences in the pattern of NMSs and predictors of quality of life may aid the development of tailored management of blepharospasm.Jing YangLingyu ZhangYanbing HouQianqian WeiRuwei OuJunyu LinWei SongBei CaoHuifang ShangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Yang Lingyu Zhang Yanbing Hou Qianqian Wei Ruwei Ou Junyu Lin Wei Song Bei Cao Huifang Shang Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
description	Abstract Idiopathic blepharospasm shows a female predominance in prevalence, whether there are sex-related differences in distributions of nonmotor symptoms (NMSs) and predictors of quality of life are unknown. Four hundred and twenty-five patients with idiopathic blepharospasm were consecutively recruited, and underwent assessments including dystonia severity, mood disturbances, sleep disturbances, cognition, ocular symptoms, and quality of life. Frequencies and distributions of NMSs, and predictors of quality of life in female and male patients were investigated. NMSs existed in majority of male (94.0%) and female (95.8%) patients. The frequencies of depression, cognition dysfunction, and poor sleep quality were higher in female patients, while the frequency of excessive daytime sleepiness was higher in male patients. More female (79.5%) patients had multiple NMS domains affected than male (70.1%) patients (p = 0.040). Quality of life was associated with depression, anxiety and motor severity for female patients (adjusted R2 = 0.367, p < 0.001), while associated with depression, excessive daytime sleepiness and motor severity for male patients (adjusted R2 = 0.430, p < 0.001). The highly prevalent coexistence of multiple NMSs found in patients with blepharospasm support that blepharospasm is a network disorder. The sex-related differences in the pattern of NMSs and predictors of quality of life may aid the development of tailored management of blepharospasm.
format	article
author	Jing Yang Lingyu Zhang Yanbing Hou Qianqian Wei Ruwei Ou Junyu Lin Wei Song Bei Cao Huifang Shang
author_facet	Jing Yang Lingyu Zhang Yanbing Hou Qianqian Wei Ruwei Ou Junyu Lin Wei Song Bei Cao Huifang Shang
author_sort	Jing Yang
title	Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
title_short	Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
title_full	Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
title_fullStr	Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
title_full_unstemmed	Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
title_sort	sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd1819d6f100487aa6ba2e9e5fa6c099
work_keys_str_mv	AT jingyang sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT lingyuzhang sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT yanbinghou sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT qianqianwei sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT ruweiou sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT junyulin sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT weisong sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT beicao sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm AT huifangshang sexrelateddifferencesinnonmotorsymptomsofpatientswithidiopathicblepharospasm
_version_	1718381062138101760

Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm

Ejemplares similares