Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.

<h4>Background</h4>After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mattijs Elschot, Bart J Vermolen, Marnix G E H Lam, Bart de Keizer, Maurice A A J van den Bosch, Hugo W A M de Jong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd1986658461495b919d06ea1f95c378
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd1986658461495b919d06ea1f95c378
record_format	dspace
spelling	oai:doaj.org-article:fd1986658461495b919d06ea1f95c3782021-11-18T07:58:31ZQuantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.1932-620310.1371/journal.pone.0055742https://doaj.org/article/fd1986658461495b919d06ea1f95c3782013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23405207/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to detect small accumulations of (90)Y and on the accuracy of liver dosimetry.<h4>Methodology/principal findings</h4>SPECT/CT and PET/CT phantom data were acquired using several acquisition and reconstruction protocols, including resolution recovery and Time-Of-Flight (TOF) PET. Image contrast and noise were compared using a torso-shaped phantom containing six hot spheres of various sizes. The ability to detect extra- and intrahepatic accumulations of activity was tested by quantitative evaluation of the visibility and unique detectability of the phantom hot spheres. Image-based dose estimates of the phantom were compared to the true dose. For clinical illustration, the SPECT and PET-based estimated liver dose distributions of five RE patients were compared. At equal noise level, PET showed higher contrast recovery coefficients than SPECT. The highest contrast recovery coefficients were obtained with TOF PET reconstruction including resolution recovery. All six spheres were consistently visible on SPECT and PET images, but PET was able to uniquely detect smaller spheres than SPECT. TOF PET-based estimates of the dose in the phantom spheres were more accurate than SPECT-based dose estimates, with underestimations ranging from 45% (10-mm sphere) to 11% (37-mm sphere) for PET, and 75% to 58% for SPECT, respectively. The differences between TOF PET and SPECT dose-estimates were supported by the patient data.<h4>Conclusions/significance</h4>In this study we quantitatively demonstrated that the image quality of state-of-the-art PET is superior over Bremsstrahlung SPECT for the assessment of the (90)Y microsphere distribution after radioembolization.Mattijs ElschotBart J VermolenMarnix G E H LamBart de KeizerMaurice A A J van den BoschHugo W A M de JongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55742 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mattijs Elschot Bart J Vermolen Marnix G E H Lam Bart de Keizer Maurice A A J van den Bosch Hugo W A M de Jong Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
description	<h4>Background</h4>After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to detect small accumulations of (90)Y and on the accuracy of liver dosimetry.<h4>Methodology/principal findings</h4>SPECT/CT and PET/CT phantom data were acquired using several acquisition and reconstruction protocols, including resolution recovery and Time-Of-Flight (TOF) PET. Image contrast and noise were compared using a torso-shaped phantom containing six hot spheres of various sizes. The ability to detect extra- and intrahepatic accumulations of activity was tested by quantitative evaluation of the visibility and unique detectability of the phantom hot spheres. Image-based dose estimates of the phantom were compared to the true dose. For clinical illustration, the SPECT and PET-based estimated liver dose distributions of five RE patients were compared. At equal noise level, PET showed higher contrast recovery coefficients than SPECT. The highest contrast recovery coefficients were obtained with TOF PET reconstruction including resolution recovery. All six spheres were consistently visible on SPECT and PET images, but PET was able to uniquely detect smaller spheres than SPECT. TOF PET-based estimates of the dose in the phantom spheres were more accurate than SPECT-based dose estimates, with underestimations ranging from 45% (10-mm sphere) to 11% (37-mm sphere) for PET, and 75% to 58% for SPECT, respectively. The differences between TOF PET and SPECT dose-estimates were supported by the patient data.<h4>Conclusions/significance</h4>In this study we quantitatively demonstrated that the image quality of state-of-the-art PET is superior over Bremsstrahlung SPECT for the assessment of the (90)Y microsphere distribution after radioembolization.
format	article
author	Mattijs Elschot Bart J Vermolen Marnix G E H Lam Bart de Keizer Maurice A A J van den Bosch Hugo W A M de Jong
author_facet	Mattijs Elschot Bart J Vermolen Marnix G E H Lam Bart de Keizer Maurice A A J van den Bosch Hugo W A M de Jong
author_sort	Mattijs Elschot
title	Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
title_short	Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
title_full	Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
title_fullStr	Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
title_full_unstemmed	Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
title_sort	quantitative comparison of pet and bremsstrahlung spect for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fd1986658461495b919d06ea1f95c378
work_keys_str_mv	AT mattijselschot quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization AT bartjvermolen quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization AT marnixgehlam quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization AT bartdekeizer quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization AT mauriceaajvandenbosch quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization AT hugowamdejong quantitativecomparisonofpetandbremsstrahlungspectforimagingtheinvivoyttrium90microspheredistributionafterliverradioembolization
_version_	1718422706216501248

Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.

Ejemplares similares