Association between frailty and the cardio-ankle vascular index

Qi Xue, Ming-zhao Qin, Jing Jia, Jin-ping Liu, Yun Wang Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China Purpose: Frailty and atherosclerotic diseases are prevalent among the older people and usually present the same pathogenesis and risk factors....

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Autores principales:	Xue Q, Qin MZ, Jia J, Liu JP, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	frailty atherosclerosis CAVI age Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fd19f0234e8346f99dd82161038b1fb0
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spelling	oai:doaj.org-article:fd19f0234e8346f99dd82161038b1fb02021-12-02T09:59:44ZAssociation between frailty and the cardio-ankle vascular index1178-1998https://doaj.org/article/fd19f0234e8346f99dd82161038b1fb02019-04-01T00:00:00Zhttps://www.dovepress.com/association-between-frailty-and-the-cardio-ankle-vascular-index-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Qi Xue, Ming-zhao Qin, Jing Jia, Jin-ping Liu, Yun Wang Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China Purpose: Frailty and atherosclerotic diseases are prevalent among the older people and usually present the same pathogenesis and risk factors. Therefore, the aim of this study was to determine the association between frailty and atherosclerosis.Patients and methods: The enrolled participants were 171 patients aged 60–96 years in Beijing Tongren Hospital. Data that were collected included sex, age, height, weight, calculated body mass index (BMI), past medical history, comorbidities (including hypertension, coronary heart disease [CHD], and diabetes), ability to perform activities of daily living (ADL) as measured using the Barthel index, handgrip strength, 15-feet (4.57 m) walking speed, body composition features determined by bioelectrical impedance analysis, the ankle–brachial index (ABI), and atherosclerosis determined by the cardio-ankle vascular index (CAVI). Patients were divided into frail, pre-frail, and non-frail groups using Fried’s frailty index. ANOVA was used to assess the differences among these groups. Linear correlation analysis was used to examine the relationship between the CAVI and frailty phenotype. Ordinal multivariate logistic regression analysis was used to examine the factors affecting frailty and the relationship between frailty and atherosclerosis.Results: The population was categorized as 21.3% frail, 38.4% pre-frail, and 40.3% non-frail. Patients in the frail group were older, had lower handgrip strength, slower walking speed, and a lower ABI and a higher proportion of carotid intima-media thickening with values of at least 1 mm compared with those in the pre-frail and non-frail groups. The CAVI score was higher in the frail group than that in the other two groups. There were significant inverse linear correlations between grip strength, walking speed, and the CAVI. CAVI showed an independent risk factor for frailty (OR: 2.013, 95% CI 1.498–2.703, p<0.001).Conclusion: Our study shows that arterial stiffness is associated with frailty in older patients, even when adjusting for multiple factors. Keywords: frailty, atherosclerosis, CAVI, ageXue QQin MZJia JLiu JPWang YDove Medical PressarticlefrailtyatherosclerosisCAVIageGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 735-742 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty atherosclerosis CAVI age Geriatrics RC952-954.6
spellingShingle	frailty atherosclerosis CAVI age Geriatrics RC952-954.6 Xue Q Qin MZ Jia J Liu JP Wang Y Association between frailty and the cardio-ankle vascular index
description	Qi Xue, Ming-zhao Qin, Jing Jia, Jin-ping Liu, Yun Wang Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China Purpose: Frailty and atherosclerotic diseases are prevalent among the older people and usually present the same pathogenesis and risk factors. Therefore, the aim of this study was to determine the association between frailty and atherosclerosis.Patients and methods: The enrolled participants were 171 patients aged 60–96 years in Beijing Tongren Hospital. Data that were collected included sex, age, height, weight, calculated body mass index (BMI), past medical history, comorbidities (including hypertension, coronary heart disease [CHD], and diabetes), ability to perform activities of daily living (ADL) as measured using the Barthel index, handgrip strength, 15-feet (4.57 m) walking speed, body composition features determined by bioelectrical impedance analysis, the ankle–brachial index (ABI), and atherosclerosis determined by the cardio-ankle vascular index (CAVI). Patients were divided into frail, pre-frail, and non-frail groups using Fried’s frailty index. ANOVA was used to assess the differences among these groups. Linear correlation analysis was used to examine the relationship between the CAVI and frailty phenotype. Ordinal multivariate logistic regression analysis was used to examine the factors affecting frailty and the relationship between frailty and atherosclerosis.Results: The population was categorized as 21.3% frail, 38.4% pre-frail, and 40.3% non-frail. Patients in the frail group were older, had lower handgrip strength, slower walking speed, and a lower ABI and a higher proportion of carotid intima-media thickening with values of at least 1 mm compared with those in the pre-frail and non-frail groups. The CAVI score was higher in the frail group than that in the other two groups. There were significant inverse linear correlations between grip strength, walking speed, and the CAVI. CAVI showed an independent risk factor for frailty (OR: 2.013, 95% CI 1.498–2.703, p<0.001).Conclusion: Our study shows that arterial stiffness is associated with frailty in older patients, even when adjusting for multiple factors. Keywords: frailty, atherosclerosis, CAVI, age
format	article
author	Xue Q Qin MZ Jia J Liu JP Wang Y
author_facet	Xue Q Qin MZ Jia J Liu JP Wang Y
author_sort	Xue Q
title	Association between frailty and the cardio-ankle vascular index
title_short	Association between frailty and the cardio-ankle vascular index
title_full	Association between frailty and the cardio-ankle vascular index
title_fullStr	Association between frailty and the cardio-ankle vascular index
title_full_unstemmed	Association between frailty and the cardio-ankle vascular index
title_sort	association between frailty and the cardio-ankle vascular index
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fd19f0234e8346f99dd82161038b1fb0
work_keys_str_mv	AT xueq associationbetweenfrailtyandthecardioanklevascularindex AT qinmz associationbetweenfrailtyandthecardioanklevascularindex AT jiaj associationbetweenfrailtyandthecardioanklevascularindex AT liujp associationbetweenfrailtyandthecardioanklevascularindex AT wangy associationbetweenfrailtyandthecardioanklevascularindex
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Association between frailty and the cardio-ankle vascular index

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