Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system.

Transmissible spongiform encephalopathies (TSEs), including scrapie in sheep (Ovis aries), are fatal neurodegenerative diseases caused by the misfolding of the cellular prion protein (PrP(C)) into a â-rich conformer (PrP(Sc)) that accumulates into higher-order structures in the brain and other tissu...

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Autores principales: Catherine E Vrentas, Justin J Greenlee, Trudy L Tatum, Eric M Nicholson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/fd1c0a5342bb469db4c04cd6110afb0c
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