Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence

Abstract In this study we aimed to explore the significance of glycemic control during gestational diabetes mellitus (GDM) pregnancy in predicting recurrence as this is unknown. A retrospective population-based cohort study of women with first diagnosed GDM pregnancy was conducted. A total of 426 wo...

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Autores principales:	Naama Schwartz, Manfred S. Green, Enav Yefet, Zohar Nachum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd1c22b891834b74b58184f7776a0650
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spelling	oai:doaj.org-article:fd1c22b891834b74b58184f7776a06502021-12-02T15:07:47ZPostprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence10.1038/s41598-018-24314-12045-2322https://doaj.org/article/fd1c22b891834b74b58184f7776a06502018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24314-1https://doaj.org/toc/2045-2322Abstract In this study we aimed to explore the significance of glycemic control during gestational diabetes mellitus (GDM) pregnancy in predicting recurrence as this is unknown. A retrospective population-based cohort study of women with first diagnosed GDM pregnancy was conducted. A total of 426 women with 4,226 glucose charts were obtained. Daily glucose values were collected from the glucose charts. Non-parametric (LOWESS) regression was used to present the glucose measurements along the gestational weeks. The analyses revealed that the 2-hour postprandial levels among women with GDM recurrence were substantially higher throughout gestation (PR = 1.89 [95% CI: 1.33, 2.73] for every 20 mg/dl increase). In a multivariable log-binomial regression, the mean postprandial glucose was significantly associated with GDM recurrence (p = 0.017) after adjusting for maternal age, family history of diabetes, insulin use, and inter-pregnancy interval (PR = 1.04 [95% CI: 1.01, 1.07]). The study conclusion is that tighter postprandial glycemic control should be considered. Future studies should explore tighter cutoffs of the 2-hour postprandial glucose.Naama SchwartzManfred S. GreenEnav YefetZohar NachumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naama Schwartz Manfred S. Green Enav Yefet Zohar Nachum Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
description	Abstract In this study we aimed to explore the significance of glycemic control during gestational diabetes mellitus (GDM) pregnancy in predicting recurrence as this is unknown. A retrospective population-based cohort study of women with first diagnosed GDM pregnancy was conducted. A total of 426 women with 4,226 glucose charts were obtained. Daily glucose values were collected from the glucose charts. Non-parametric (LOWESS) regression was used to present the glucose measurements along the gestational weeks. The analyses revealed that the 2-hour postprandial levels among women with GDM recurrence were substantially higher throughout gestation (PR = 1.89 [95% CI: 1.33, 2.73] for every 20 mg/dl increase). In a multivariable log-binomial regression, the mean postprandial glucose was significantly associated with GDM recurrence (p = 0.017) after adjusting for maternal age, family history of diabetes, insulin use, and inter-pregnancy interval (PR = 1.04 [95% CI: 1.01, 1.07]). The study conclusion is that tighter postprandial glycemic control should be considered. Future studies should explore tighter cutoffs of the 2-hour postprandial glucose.
format	article
author	Naama Schwartz Manfred S. Green Enav Yefet Zohar Nachum
author_facet	Naama Schwartz Manfred S. Green Enav Yefet Zohar Nachum
author_sort	Naama Schwartz
title	Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
title_short	Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
title_full	Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
title_fullStr	Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
title_full_unstemmed	Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
title_sort	postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fd1c22b891834b74b58184f7776a0650
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Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence

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