Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients

Background: Diabetic retinopathy is a common deficiency of diabetes mellitus. Diabetic macular ischemia [DMI] is a permanent form of diabetic maculopathy, and its presence reduces the potential benefits of diabetic retinopathy management. Optical coherence tomography [OCT] is used to precisely and r...

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Autores principales:	Sherif Ahmed Shawky, Sawsan Abd El Sabour Shalaby, Nesma Sayed Mohammed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	optical coherence tomography angiography diabetic macular ischemia deep capillary plexus capillary non perfusion disorganization of the retinal inner layers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fd1ee4e943ad4f368bf5c12e178eb97a
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spelling	oai:doaj.org-article:fd1ee4e943ad4f368bf5c12e178eb97a2021-12-02T15:42:54ZCorrelation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients2636-41742682-378010.21608/ijma.2021.47804.1199https://doaj.org/article/fd1ee4e943ad4f368bf5c12e178eb97a2021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_146910_9d533bf0ea1fc5d2fd7afad3ba42f0d0.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Diabetic retinopathy is a common deficiency of diabetes mellitus. Diabetic macular ischemia [DMI] is a permanent form of diabetic maculopathy, and its presence reduces the potential benefits of diabetic retinopathy management. Optical coherence tomography [OCT] is used to precisely and reliably measure the macular thickness and outline the retinal layers. Optical coherence tomography angiography [OCTA] can be utilized as a reliable tool to classify the superficial capillary plexus [SCP], the deep capillary plexus [DCP] and the capillary non-perfusion [NP]. Aim of the work: The current research aimed to investigate the correlation between macular non-perfusion that diagnosed by OCTA and patterns of macular layers that diagnosed by OCT scans through the same parts, in a trial to help in the evaluation of both structural and vascular integrity. Patients and Methods: The study included 250 eyes of 125 diabetic patients. All study participants were scanned by OCTA. OCT angiograms were re-sampled with OCT scans from the same region, permitting synchronous evaluation of structure and blood flow. Results: 250 of 125 diabetic patients were categorized into two groups according to capillary NP, ischemic [G1] and non-ischemic [G2]. In current study the incidence of DMI was 40%. The incidence of DCPNP was 100% in eyes with DMI while the incidence of SCPNP was 71%. The incidence of foveal avascular zone [FAZ] irregularity, disorganization of the retinal inner layers [DRIL], inner/outer segment IS/OS and external limiting membrane ELM disruptions were 100%, 83%, 95%, 71% respectively among eyes with DMI. DCPNP was more found in all eyes with FAZ irregularity, DRIL, IS/OS and ELM disruption than SCP NP which makes it as the central cause of structural changes in the retina during ischemia. There was a strong positive correlation between the appearance of FAZ irregularity, DRIL, IS/OS and ELM disruption with each of the duration and severity of DR. Conclusion: FAZ irregularity, DRIL, IS/OS and ELM disruption are considered reliable OCT/OCTA findings that reflect an underling DMI and their existence can influence the visual prognosis.Sherif Ahmed ShawkySawsan Abd El Sabour ShalabyNesma Sayed MohammedAl-Azhar University, Faculty of Medicine (Damietta)articleoptical coherence tomography angiographydiabetic macular ischemiadeep capillary plexuscapillary non perfusiondisorganization of the retinal inner layersMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1208-1214 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography angiography diabetic macular ischemia deep capillary plexus capillary non perfusion disorganization of the retinal inner layers Medicine (General) R5-920
spellingShingle	optical coherence tomography angiography diabetic macular ischemia deep capillary plexus capillary non perfusion disorganization of the retinal inner layers Medicine (General) R5-920 Sherif Ahmed Shawky Sawsan Abd El Sabour Shalaby Nesma Sayed Mohammed Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
description	Background: Diabetic retinopathy is a common deficiency of diabetes mellitus. Diabetic macular ischemia [DMI] is a permanent form of diabetic maculopathy, and its presence reduces the potential benefits of diabetic retinopathy management. Optical coherence tomography [OCT] is used to precisely and reliably measure the macular thickness and outline the retinal layers. Optical coherence tomography angiography [OCTA] can be utilized as a reliable tool to classify the superficial capillary plexus [SCP], the deep capillary plexus [DCP] and the capillary non-perfusion [NP]. Aim of the work: The current research aimed to investigate the correlation between macular non-perfusion that diagnosed by OCTA and patterns of macular layers that diagnosed by OCT scans through the same parts, in a trial to help in the evaluation of both structural and vascular integrity. Patients and Methods: The study included 250 eyes of 125 diabetic patients. All study participants were scanned by OCTA. OCT angiograms were re-sampled with OCT scans from the same region, permitting synchronous evaluation of structure and blood flow. Results: 250 of 125 diabetic patients were categorized into two groups according to capillary NP, ischemic [G1] and non-ischemic [G2]. In current study the incidence of DMI was 40%. The incidence of DCPNP was 100% in eyes with DMI while the incidence of SCPNP was 71%. The incidence of foveal avascular zone [FAZ] irregularity, disorganization of the retinal inner layers [DRIL], inner/outer segment IS/OS and external limiting membrane ELM disruptions were 100%, 83%, 95%, 71% respectively among eyes with DMI. DCPNP was more found in all eyes with FAZ irregularity, DRIL, IS/OS and ELM disruption than SCP NP which makes it as the central cause of structural changes in the retina during ischemia. There was a strong positive correlation between the appearance of FAZ irregularity, DRIL, IS/OS and ELM disruption with each of the duration and severity of DR. Conclusion: FAZ irregularity, DRIL, IS/OS and ELM disruption are considered reliable OCT/OCTA findings that reflect an underling DMI and their existence can influence the visual prognosis.
format	article
author	Sherif Ahmed Shawky Sawsan Abd El Sabour Shalaby Nesma Sayed Mohammed
author_facet	Sherif Ahmed Shawky Sawsan Abd El Sabour Shalaby Nesma Sayed Mohammed
author_sort	Sherif Ahmed Shawky
title	Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
title_short	Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
title_full	Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
title_fullStr	Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
title_full_unstemmed	Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients
title_sort	correlation between macular non-perfusion and patterns of corresponding retinal layers in diabetic patients
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/fd1ee4e943ad4f368bf5c12e178eb97a
work_keys_str_mv	AT sherifahmedshawky correlationbetweenmacularnonperfusionandpatternsofcorrespondingretinallayersindiabeticpatients AT sawsanabdelsabourshalaby correlationbetweenmacularnonperfusionandpatternsofcorrespondingretinallayersindiabeticpatients AT nesmasayedmohammed correlationbetweenmacularnonperfusionandpatternsofcorrespondingretinallayersindiabeticpatients
_version_	1718385849396101120

Correlation between Macular Non-Perfusion and Patterns of Corresponding Retinal Layers in Diabetic Patients

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