Co-occupancy identifies transcription factor co-operation for axon growth

After injury to the nervous system, many neurons fail to initiate transcriptional programs needed for axon growth. Here the authors examine co-operative binding of factors to regulatory DNA to predict combinations that improve axon growth when ectopically co-expressed.

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Autores principales:	Ishwariya Venkatesh, Vatsal Mehra, Zimei Wang, Matthew T. Simpson, Erik Eastwood, Advaita Chakraborty, Zac Beine, Derek Gross, Michael Cabahug, Greta Olson, Murray G. Blackmore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd22a732183e4c72a9a568ef622f169e
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spelling	oai:doaj.org-article:fd22a732183e4c72a9a568ef622f169e2021-12-02T14:49:23ZCo-occupancy identifies transcription factor co-operation for axon growth10.1038/s41467-021-22828-32041-1723https://doaj.org/article/fd22a732183e4c72a9a568ef622f169e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22828-3https://doaj.org/toc/2041-1723After injury to the nervous system, many neurons fail to initiate transcriptional programs needed for axon growth. Here the authors examine co-operative binding of factors to regulatory DNA to predict combinations that improve axon growth when ectopically co-expressed.Ishwariya VenkateshVatsal MehraZimei WangMatthew T. SimpsonErik EastwoodAdvaita ChakrabortyZac BeineDerek GrossMichael CabahugGreta OlsonMurray G. BlackmoreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ishwariya Venkatesh Vatsal Mehra Zimei Wang Matthew T. Simpson Erik Eastwood Advaita Chakraborty Zac Beine Derek Gross Michael Cabahug Greta Olson Murray G. Blackmore Co-occupancy identifies transcription factor co-operation for axon growth
description	After injury to the nervous system, many neurons fail to initiate transcriptional programs needed for axon growth. Here the authors examine co-operative binding of factors to regulatory DNA to predict combinations that improve axon growth when ectopically co-expressed.
format	article
author	Ishwariya Venkatesh Vatsal Mehra Zimei Wang Matthew T. Simpson Erik Eastwood Advaita Chakraborty Zac Beine Derek Gross Michael Cabahug Greta Olson Murray G. Blackmore
author_facet	Ishwariya Venkatesh Vatsal Mehra Zimei Wang Matthew T. Simpson Erik Eastwood Advaita Chakraborty Zac Beine Derek Gross Michael Cabahug Greta Olson Murray G. Blackmore
author_sort	Ishwariya Venkatesh
title	Co-occupancy identifies transcription factor co-operation for axon growth
title_short	Co-occupancy identifies transcription factor co-operation for axon growth
title_full	Co-occupancy identifies transcription factor co-operation for axon growth
title_fullStr	Co-occupancy identifies transcription factor co-operation for axon growth
title_full_unstemmed	Co-occupancy identifies transcription factor co-operation for axon growth
title_sort	co-occupancy identifies transcription factor co-operation for axon growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd22a732183e4c72a9a568ef622f169e
work_keys_str_mv	AT ishwariyavenkatesh cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT vatsalmehra cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT zimeiwang cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT matthewtsimpson cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT erikeastwood cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT advaitachakraborty cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT zacbeine cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT derekgross cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT michaelcabahug cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT gretaolson cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth AT murraygblackmore cooccupancyidentifiestranscriptionfactorcooperationforaxongrowth
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Co-occupancy identifies transcription factor co-operation for axon growth

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