Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.

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Autores principales: Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fd236016877346748003cdfce0070291
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spelling oai:doaj.org-article:fd236016877346748003cdfce00702912021-12-02T14:39:21ZSomatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling10.1038/s41467-018-03731-w2041-1723https://doaj.org/article/fd236016877346748003cdfce00702912018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03731-whttps://doaj.org/toc/2041-1723Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.Barbara OldriniÁlvaro Curiel-GarcíaCarolina MarquesVeronica MatiaÖzge UluçkanOsvaldo Graña-CastroRaul Torres-RuizSandra Rodriguez-PeralesJason T. HuseMassimo SquatritoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Barbara Oldrini
Álvaro Curiel-García
Carolina Marques
Veronica Matia
Özge Uluçkan
Osvaldo Graña-Castro
Raul Torres-Ruiz
Sandra Rodriguez-Perales
Jason T. Huse
Massimo Squatrito
Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
description Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.
format article
author Barbara Oldrini
Álvaro Curiel-García
Carolina Marques
Veronica Matia
Özge Uluçkan
Osvaldo Graña-Castro
Raul Torres-Ruiz
Sandra Rodriguez-Perales
Jason T. Huse
Massimo Squatrito
author_facet Barbara Oldrini
Álvaro Curiel-García
Carolina Marques
Veronica Matia
Özge Uluçkan
Osvaldo Graña-Castro
Raul Torres-Ruiz
Sandra Rodriguez-Perales
Jason T. Huse
Massimo Squatrito
author_sort Barbara Oldrini
title Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
title_short Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
title_full Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
title_fullStr Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
title_full_unstemmed Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
title_sort somatic genome editing with the rcas-tva-crispr-cas9 system for precision tumor modeling
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fd236016877346748003cdfce0070291
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AT alvarocurielgarcia somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT carolinamarques somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT veronicamatia somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT ozgeuluckan somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
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AT raultorresruiz somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT sandrarodriguezperales somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT jasonthuse somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
AT massimosquatrito somaticgenomeeditingwiththercastvacrisprcas9systemforprecisiontumormodeling
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