The role of difluprednate ophthalmic emulsion in clinical practice
Karim N Jamal1,2, David G Callanan11Texas Retina Associates, Arlington, Texas, USA; 2Current affiliation: Retinal Consultants of Arizona, Phoenix, Arizona, USAAbstract: The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agent...
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Dove Medical Press
2009
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oai:doaj.org-article:fd236e7436c94fffad716c56ae4ccaab2021-12-02T07:03:49ZThe role of difluprednate ophthalmic emulsion in clinical practice1177-54671177-5483https://doaj.org/article/fd236e7436c94fffad716c56ae4ccaab2009-06-01T00:00:00Zhttp://www.dovepress.com/the-role-of-difluprednate-ophthalmic-emulsion-in-clinical-practice-a3308https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Karim N Jamal1,2, David G Callanan11Texas Retina Associates, Arlington, Texas, USA; 2Current affiliation: Retinal Consultants of Arizona, Phoenix, Arizona, USAAbstract: The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits are the strong steroids, such as prednisolone acetate and betamethasone. This review aims to cover the biochemistry and drug development of difluprednate, a novel synthetic strong steroid emulsion. In vivo pharmacokinetics as well as ocular distribution and metabolism are discussed, followed by a comprehensive summary of phase I, II, and III clinical trials evaluating safety and efficacy in patients suffering from postoperative inflammation or anterior uveitis. The objective is to provide an increased familiarity with this newly approved medication as a welcome addition to the ophthalmologist’s armamentarium.Keywords: difluprednate, steroid, emulsion, ophthalmic surgery Karim N JamalDavid G CallananDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 381-390 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Ophthalmology RE1-994 |
| spellingShingle |
Ophthalmology RE1-994 Karim N Jamal David G Callanan The role of difluprednate ophthalmic emulsion in clinical practice |
| description |
Karim N Jamal1,2, David G Callanan11Texas Retina Associates, Arlington, Texas, USA; 2Current affiliation: Retinal Consultants of Arizona, Phoenix, Arizona, USAAbstract: The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits are the strong steroids, such as prednisolone acetate and betamethasone. This review aims to cover the biochemistry and drug development of difluprednate, a novel synthetic strong steroid emulsion. In vivo pharmacokinetics as well as ocular distribution and metabolism are discussed, followed by a comprehensive summary of phase I, II, and III clinical trials evaluating safety and efficacy in patients suffering from postoperative inflammation or anterior uveitis. The objective is to provide an increased familiarity with this newly approved medication as a welcome addition to the ophthalmologist’s armamentarium.Keywords: difluprednate, steroid, emulsion, ophthalmic surgery |
| format |
article |
| author |
Karim N Jamal David G Callanan |
| author_facet |
Karim N Jamal David G Callanan |
| author_sort |
Karim N Jamal |
| title |
The role of difluprednate ophthalmic emulsion in clinical practice |
| title_short |
The role of difluprednate ophthalmic emulsion in clinical practice |
| title_full |
The role of difluprednate ophthalmic emulsion in clinical practice |
| title_fullStr |
The role of difluprednate ophthalmic emulsion in clinical practice |
| title_full_unstemmed |
The role of difluprednate ophthalmic emulsion in clinical practice |
| title_sort |
role of difluprednate ophthalmic emulsion in clinical practice |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/fd236e7436c94fffad716c56ae4ccaab |
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