Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (Angpt2) enhances SAT size via increased endothelia...

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Autores principales:	Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee, Gou Young Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd246ddc209c49668f2467366b4c24ec
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spelling	oai:doaj.org-article:fd246ddc209c49668f2467366b4c24ec2021-12-02T17:52:20ZAngiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance10.1038/s41467-020-16795-42041-1723https://doaj.org/article/fd246ddc209c49668f2467366b4c24ec2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16795-4https://doaj.org/toc/2041-1723Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (Angpt2) enhances SAT size via increased endothelial fatty acid transport.Hosung BaeKi Yong HongChoong-kun LeeCholsoon JangSeung-Jun LeeKibaek ChoeStefan OffermannsYulong HeHyuek Jong LeeGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hosung Bae Ki Yong Hong Choong-kun Lee Cholsoon Jang Seung-Jun Lee Kibaek Choe Stefan Offermanns Yulong He Hyuek Jong Lee Gou Young Koh Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
description	Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (Angpt2) enhances SAT size via increased endothelial fatty acid transport.
format	article
author	Hosung Bae Ki Yong Hong Choong-kun Lee Cholsoon Jang Seung-Jun Lee Kibaek Choe Stefan Offermanns Yulong He Hyuek Jong Lee Gou Young Koh
author_facet	Hosung Bae Ki Yong Hong Choong-kun Lee Cholsoon Jang Seung-Jun Lee Kibaek Choe Stefan Offermanns Yulong He Hyuek Jong Lee Gou Young Koh
author_sort	Hosung Bae
title	Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
title_short	Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
title_full	Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
title_fullStr	Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
title_full_unstemmed	Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
title_sort	angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd246ddc209c49668f2467366b4c24ec
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Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

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