CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION

Objective: The objective of this study focuses to unfold the importance of creatinine clearance in determining the gastrointestinal mani-festations and Helicobacter Pylori infection. Study Design: Cross-sectional comparative study. Place and Duration of Study: Medicine department of Fauji Foundat...

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Autores principales:	Zubia Jamil, Saima Ambreen, Omar Ahsan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	chronic kidney disease creatinine endoscopy gastritis helicobacter pylori Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fd25aa5130f14392a741da54a1aeb188
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spelling	oai:doaj.org-article:fd25aa5130f14392a741da54a1aeb1882021-12-02T02:49:00ZCREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION0030-96482411-8842https://doaj.org/article/fd25aa5130f14392a741da54a1aeb1882018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2283/1980https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: The objective of this study focuses to unfold the importance of creatinine clearance in determining the gastrointestinal mani-festations and Helicobacter Pylori infection. Study Design: Cross-sectional comparative study. Place and Duration of Study: Medicine department of Fauji Foundation Hospital Rawalpindi, from Jun 2015 to Dec 2016. Material and Methods: Creatinine clearance of 73 CKD patients was calculated. UGI endoscopy was performed to detect gastro-intestinal lesions. H.pylori was detected by histopathology of gastric mucosal biopsy. The diagnostic accuracy of CCl in determining the presence of gastrointestinal (GI) lesions was determined by receiver operating characteristic (ROC) curve (AUC). Cut-off value, sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios were obtained by Youden index. Results: Mean CCl was 27.09 ± 12.16 ml/min. Diabetes mellitus was the top most cause of CKD (45.2%). Upper GI endoscopic lesions were present in 68.5% patients (p-value<0.05). The most common abnormality was erythematous gastritis. H. pylori infection was lower in disease group compared to controls, but statistically insignificant (p>0.05). The AUC for CCl in determining the gastrointestinal lesions was 0.8 (p-value≤0.0001), cutoff value was <35ml/min (Sensitivity 81.82%, Specificity 72.4%). The AUC for CCl in determining the presence of H. Pylori infection was 0.7 (p-value=0.0004), cutoff value was <27 ml/min (Sensitivity 83.33%, Specificity 58.18%). Conclusion: CCl was found, noninvasive marker in predicting the GI abnormalities. It can be used to identify the high risk patients. Such patients then can undergo endoscopy for further management. H.pylori eradication therapy should be offered to those patients in whom its presence is proven by other tests as well.Zubia JamilSaima AmbreenOmar AhsanArmy Medical College Rawalpindiarticlechronic kidney diseasecreatinineendoscopygastritishelicobacter pyloriMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1161-1167 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease creatinine endoscopy gastritis helicobacter pylori Medicine R Medicine (General) R5-920
spellingShingle	chronic kidney disease creatinine endoscopy gastritis helicobacter pylori Medicine R Medicine (General) R5-920 Zubia Jamil Saima Ambreen Omar Ahsan CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
description	Objective: The objective of this study focuses to unfold the importance of creatinine clearance in determining the gastrointestinal mani-festations and Helicobacter Pylori infection. Study Design: Cross-sectional comparative study. Place and Duration of Study: Medicine department of Fauji Foundation Hospital Rawalpindi, from Jun 2015 to Dec 2016. Material and Methods: Creatinine clearance of 73 CKD patients was calculated. UGI endoscopy was performed to detect gastro-intestinal lesions. H.pylori was detected by histopathology of gastric mucosal biopsy. The diagnostic accuracy of CCl in determining the presence of gastrointestinal (GI) lesions was determined by receiver operating characteristic (ROC) curve (AUC). Cut-off value, sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios were obtained by Youden index. Results: Mean CCl was 27.09 ± 12.16 ml/min. Diabetes mellitus was the top most cause of CKD (45.2%). Upper GI endoscopic lesions were present in 68.5% patients (p-value<0.05). The most common abnormality was erythematous gastritis. H. pylori infection was lower in disease group compared to controls, but statistically insignificant (p>0.05). The AUC for CCl in determining the gastrointestinal lesions was 0.8 (p-value≤0.0001), cutoff value was <35ml/min (Sensitivity 81.82%, Specificity 72.4%). The AUC for CCl in determining the presence of H. Pylori infection was 0.7 (p-value=0.0004), cutoff value was <27 ml/min (Sensitivity 83.33%, Specificity 58.18%). Conclusion: CCl was found, noninvasive marker in predicting the GI abnormalities. It can be used to identify the high risk patients. Such patients then can undergo endoscopy for further management. H.pylori eradication therapy should be offered to those patients in whom its presence is proven by other tests as well.
format	article
author	Zubia Jamil Saima Ambreen Omar Ahsan
author_facet	Zubia Jamil Saima Ambreen Omar Ahsan
author_sort	Zubia Jamil
title	CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
title_short	CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
title_full	CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
title_fullStr	CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
title_full_unstemmed	CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION
title_sort	creatinine clearance as effective non-invasive marker in determining gastrointestinal lesions and helicobacter pylori infection
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/fd25aa5130f14392a741da54a1aeb188
work_keys_str_mv	AT zubiajamil creatinineclearanceaseffectivenoninvasivemarkerindetermininggastrointestinallesionsandhelicobacterpyloriinfection AT saimaambreen creatinineclearanceaseffectivenoninvasivemarkerindetermininggastrointestinallesionsandhelicobacterpyloriinfection AT omarahsan creatinineclearanceaseffectivenoninvasivemarkerindetermininggastrointestinallesionsandhelicobacterpyloriinfection
_version_	1718402140477587456

CREATININE CLEARANCE AS EFFECTIVE NON-INVASIVE MARKER IN DETERMINING GASTROINTESTINAL LESIONS AND HELICOBACTER PYLORI INFECTION

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