A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.

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Autores principales: Juan P. Castillo, Alexander B. Tong, Sara Tafoya, Paul J. Jardine, Carlos Bustamante
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fd2702eb7c8e4254a416e2dbc6cb6580
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