The risk factors of bone metastases in patients with lung cancer

Abstract The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer we...

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Autores principales:	Yang Zhou, Qing-Fu Yu, Ai-Fen Peng, Wei-Lai Tong, Jia-Ming Liu, Zhi-Li Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd2913af340e434ca17613f477908a66
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spelling	oai:doaj.org-article:fd2913af340e434ca17613f477908a662021-12-02T15:05:56ZThe risk factors of bone metastases in patients with lung cancer10.1038/s41598-017-09650-y2045-2322https://doaj.org/article/fd2913af340e434ca17613f477908a662017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09650-yhttps://doaj.org/toc/2045-2322Abstract The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer were included in this study and 23.9% of them were found to be bone metastases. For patients with bone metastases, adenocarcinoma (62.1%) was the most common pathological subtype, and rib (62.3%) was the most frequent distant metastatic site, followed by thoracic (53.8%) and lumbar spine (40.4%). The histopathologic type, CA-125 level and the concentration of alkaline phosphatase (ALP) were identified as the independent risk factors for bone metastases in lung cancer (P = 0.002, P = 0.001 and P < 0.001). The sensitivities and specificities of diagnosing bone metastasis by CA-125 were 32.1% and 80.8%, and by ALP were 41.3% and 77.1%, respectively. Thus, the incidence of bone metastases in lung cancer patients was relative high, and physicians should pay attention to the histopathologic type, the serum CA-125 and ALP concentrations when patients were firstly diagnosed with lung cancer for early detecting bone metastases.Yang ZhouQing-Fu YuAi-Fen PengWei-Lai TongJia-Ming LiuZhi-Li LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Zhou Qing-Fu Yu Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu The risk factors of bone metastases in patients with lung cancer
description	Abstract The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer were included in this study and 23.9% of them were found to be bone metastases. For patients with bone metastases, adenocarcinoma (62.1%) was the most common pathological subtype, and rib (62.3%) was the most frequent distant metastatic site, followed by thoracic (53.8%) and lumbar spine (40.4%). The histopathologic type, CA-125 level and the concentration of alkaline phosphatase (ALP) were identified as the independent risk factors for bone metastases in lung cancer (P = 0.002, P = 0.001 and P < 0.001). The sensitivities and specificities of diagnosing bone metastasis by CA-125 were 32.1% and 80.8%, and by ALP were 41.3% and 77.1%, respectively. Thus, the incidence of bone metastases in lung cancer patients was relative high, and physicians should pay attention to the histopathologic type, the serum CA-125 and ALP concentrations when patients were firstly diagnosed with lung cancer for early detecting bone metastases.
format	article
author	Yang Zhou Qing-Fu Yu Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu
author_facet	Yang Zhou Qing-Fu Yu Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu
author_sort	Yang Zhou
title	The risk factors of bone metastases in patients with lung cancer
title_short	The risk factors of bone metastases in patients with lung cancer
title_full	The risk factors of bone metastases in patients with lung cancer
title_fullStr	The risk factors of bone metastases in patients with lung cancer
title_full_unstemmed	The risk factors of bone metastases in patients with lung cancer
title_sort	risk factors of bone metastases in patients with lung cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fd2913af340e434ca17613f477908a66
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The risk factors of bone metastases in patients with lung cancer

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