Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

The function of metabolic genes in the context of regulatory networks is not well understood. Here, the authors investigate the adaptive responses of E. coli after knockout of metabolic genes and highlight the influence of metabolite levels in the evolution of regulatory function.

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Autores principales:	Douglas McCloskey, Sibei Xu, Troy E. Sandberg, Elizabeth Brunk, Ying Hefner, Richard Szubin, Adam M. Feist, Bernhard O. Palsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd2b6a0b1c8a4b8887b01196d94ac11c
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spelling	oai:doaj.org-article:fd2b6a0b1c8a4b8887b01196d94ac11c2021-12-02T15:33:44ZEvolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism10.1038/s41467-018-06219-92041-1723https://doaj.org/article/fd2b6a0b1c8a4b8887b01196d94ac11c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06219-9https://doaj.org/toc/2041-1723The function of metabolic genes in the context of regulatory networks is not well understood. Here, the authors investigate the adaptive responses of E. coli after knockout of metabolic genes and highlight the influence of metabolite levels in the evolution of regulatory function.Douglas McCloskeySibei XuTroy E. SandbergElizabeth BrunkYing HefnerRichard SzubinAdam M. FeistBernhard O. PalssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Douglas McCloskey Sibei Xu Troy E. Sandberg Elizabeth Brunk Ying Hefner Richard Szubin Adam M. Feist Bernhard O. Palsson Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
description	The function of metabolic genes in the context of regulatory networks is not well understood. Here, the authors investigate the adaptive responses of E. coli after knockout of metabolic genes and highlight the influence of metabolite levels in the evolution of regulatory function.
format	article
author	Douglas McCloskey Sibei Xu Troy E. Sandberg Elizabeth Brunk Ying Hefner Richard Szubin Adam M. Feist Bernhard O. Palsson
author_facet	Douglas McCloskey Sibei Xu Troy E. Sandberg Elizabeth Brunk Ying Hefner Richard Szubin Adam M. Feist Bernhard O. Palsson
author_sort	Douglas McCloskey
title	Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
title_short	Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
title_full	Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
title_fullStr	Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
title_full_unstemmed	Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
title_sort	evolution of gene knockout strains of e. coli reveal regulatory architectures governed by metabolism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fd2b6a0b1c8a4b8887b01196d94ac11c
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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

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