Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles

Mohammad Farazuddin1, Bhawna Sharma2, Aijaz Ahmed Khan3, Beenu Joshi2, Mohammad Owais11Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India; 2Immunology Division, NJIL and other Mycobacterial diseases, Agra-282001, Uttar Pradesh, India; 3Department of Anatom...

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Autores principales:	Farazuddin M, Sharma B, Khan AA, Joshi B, Owais M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fd2bf757283548ae90942b6e77fb6c02
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spelling	oai:doaj.org-article:fd2bf757283548ae90942b6e77fb6c022021-12-02T05:55:47ZAnticancer efficacy of perillyl alcohol-bearing PLGA microparticles1176-91141178-2013https://doaj.org/article/fd2bf757283548ae90942b6e77fb6c022012-01-01T00:00:00Zhttp://www.dovepress.com/anticancer-efficacy-of-perillyl-alcohol-bearing-plga-microparticles-a8999https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mohammad Farazuddin1, Bhawna Sharma2, Aijaz Ahmed Khan3, Beenu Joshi2, Mohammad Owais11Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India; 2Immunology Division, NJIL and other Mycobacterial diseases, Agra-282001, Uttar Pradesh, India; 3Department of Anatomy, JN Medical college, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh, IndiaAbstract: In the present study, a novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) was prepared and characterized. Further, its efficacy was evaluated against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice. The characterization studies showed that POH-bearing PLGA microparticles were of the size 768 &plusmn; 215 nm with a &zeta;-potential value of -7.56 &plusmn; 0.88 mV. The entrapment efficiency of the active drug in particles was 42.4% &plusmn; 3.5%. POH-bearing PLGA microparticles were stable and released entrapped drug gradually over an extended time period. The in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (~80%) as compared with the group receiving free form of POH (survival rate 40%). The superiority of POH-PLGA microparticles over free form of POH was further evident from their ability to modulate apoptosis-regulating factors.Keywords: poly-lactic glycolic acid, epidermoid cancer cells, skin papilloma, anticancer efficacyFarazuddin MSharma BKhan AAJoshi BOwais MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 35-47 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Farazuddin M Sharma B Khan AA Joshi B Owais M Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
description	Mohammad Farazuddin1, Bhawna Sharma2, Aijaz Ahmed Khan3, Beenu Joshi2, Mohammad Owais11Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India; 2Immunology Division, NJIL and other Mycobacterial diseases, Agra-282001, Uttar Pradesh, India; 3Department of Anatomy, JN Medical college, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh, IndiaAbstract: In the present study, a novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) was prepared and characterized. Further, its efficacy was evaluated against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice. The characterization studies showed that POH-bearing PLGA microparticles were of the size 768 &plusmn; 215 nm with a &zeta;-potential value of -7.56 &plusmn; 0.88 mV. The entrapment efficiency of the active drug in particles was 42.4% &plusmn; 3.5%. POH-bearing PLGA microparticles were stable and released entrapped drug gradually over an extended time period. The in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (~80%) as compared with the group receiving free form of POH (survival rate 40%). The superiority of POH-PLGA microparticles over free form of POH was further evident from their ability to modulate apoptosis-regulating factors.Keywords: poly-lactic glycolic acid, epidermoid cancer cells, skin papilloma, anticancer efficacy
format	article
author	Farazuddin M Sharma B Khan AA Joshi B Owais M
author_facet	Farazuddin M Sharma B Khan AA Joshi B Owais M
author_sort	Farazuddin M
title	Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
title_short	Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
title_full	Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
title_fullStr	Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
title_full_unstemmed	Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
title_sort	anticancer efficacy of perillyl alcohol-bearing plga microparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/fd2bf757283548ae90942b6e77fb6c02
work_keys_str_mv	AT farazuddinm anticancerefficacyofperillylalcoholbearingplgamicroparticles AT sharmab anticancerefficacyofperillylalcoholbearingplgamicroparticles AT khanaa anticancerefficacyofperillylalcoholbearingplgamicroparticles AT joshib anticancerefficacyofperillylalcoholbearingplgamicroparticles AT owaism anticancerefficacyofperillylalcoholbearingplgamicroparticles
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Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles

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