Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma

Abstract This study assesses the safety and efficacy of microinvasive glaucoma surgery (MIGS) with cataract extraction in patients with normal-tension glaucoma (NTG). In our sample of 45 NTG patients, mean intraocular pressure (IOP) decreased from 13.7 to 12.3 mmHg at 2.5 years, and mean medication...

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Autores principales:	Enchi Kristina Chang, Sanchay Gupta, Marika Chachanidze, Nathan Hall, Ta Chen Chang, David Solá-Del Valle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd370959151e4b10968b46ea49147154
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spelling	oai:doaj.org-article:fd370959151e4b10968b46ea491471542021-12-02T13:41:22ZSafety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma10.1038/s41598-021-88358-62045-2322https://doaj.org/article/fd370959151e4b10968b46ea491471542021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88358-6https://doaj.org/toc/2045-2322Abstract This study assesses the safety and efficacy of microinvasive glaucoma surgery (MIGS) with cataract extraction in patients with normal-tension glaucoma (NTG). In our sample of 45 NTG patients, mean intraocular pressure (IOP) decreased from 13.7 to 12.3 mmHg at 2.5 years, and mean medication burden decreased from 2.0 to 1.1 at 1.5 years. For success defined as IOP reduction ≥ 30% from baseline IOP with medication burden reduction from preoperative levels, success probability was 5.4% at 1.5 years. For success defined as medication burden reduction with an IOP reaching goal IOP as determined by the glaucoma specialist, success probabilities were 67.2% at 1.5 years and 29.4% at 2.5 years. At the last follow-up visit, eyes with two MIGS procedures with different mechanisms of action achieved successful medication reduction 68.8% of the time versus 35.7% achieved by a single MIGS procedure (p = 0.052). At their last visit, visual acuity was unchanged or improved in all eyes (100%). MIGS with cataract surgery results in modest reductions in IOP and medication burden in NTG patients, which may lead to lower costs and better therapeutic compliance. A combination of two MIGS procedures with different mechanisms of action may potentially be more effective in reducing medication burden than a single MIGS procedure in NTG patients. Further research is necessary to ascertain whether MIGS for NTG patients may help decrease medication burden while helping achieve goal IOP.Enchi Kristina ChangSanchay GuptaMarika ChachanidzeNathan HallTa Chen ChangDavid Solá-Del ValleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enchi Kristina Chang Sanchay Gupta Marika Chachanidze Nathan Hall Ta Chen Chang David Solá-Del Valle Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
description	Abstract This study assesses the safety and efficacy of microinvasive glaucoma surgery (MIGS) with cataract extraction in patients with normal-tension glaucoma (NTG). In our sample of 45 NTG patients, mean intraocular pressure (IOP) decreased from 13.7 to 12.3 mmHg at 2.5 years, and mean medication burden decreased from 2.0 to 1.1 at 1.5 years. For success defined as IOP reduction ≥ 30% from baseline IOP with medication burden reduction from preoperative levels, success probability was 5.4% at 1.5 years. For success defined as medication burden reduction with an IOP reaching goal IOP as determined by the glaucoma specialist, success probabilities were 67.2% at 1.5 years and 29.4% at 2.5 years. At the last follow-up visit, eyes with two MIGS procedures with different mechanisms of action achieved successful medication reduction 68.8% of the time versus 35.7% achieved by a single MIGS procedure (p = 0.052). At their last visit, visual acuity was unchanged or improved in all eyes (100%). MIGS with cataract surgery results in modest reductions in IOP and medication burden in NTG patients, which may lead to lower costs and better therapeutic compliance. A combination of two MIGS procedures with different mechanisms of action may potentially be more effective in reducing medication burden than a single MIGS procedure in NTG patients. Further research is necessary to ascertain whether MIGS for NTG patients may help decrease medication burden while helping achieve goal IOP.
format	article
author	Enchi Kristina Chang Sanchay Gupta Marika Chachanidze Nathan Hall Ta Chen Chang David Solá-Del Valle
author_facet	Enchi Kristina Chang Sanchay Gupta Marika Chachanidze Nathan Hall Ta Chen Chang David Solá-Del Valle
author_sort	Enchi Kristina Chang
title	Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
title_short	Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
title_full	Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
title_fullStr	Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
title_full_unstemmed	Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
title_sort	safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd370959151e4b10968b46ea49147154
work_keys_str_mv	AT enchikristinachang safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma AT sanchaygupta safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma AT marikachachanidze safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma AT nathanhall safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma AT tachenchang safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma AT davidsoladelvalle safetyandefficacyofmicroinvasiveglaucomasurgerywithcataractextractioninpatientswithnormaltensionglaucoma
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Safety and efficacy of microinvasive glaucoma surgery with cataract extraction in patients with normal-tension glaucoma

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