A novel role for the actin-binding protein drebrin in regulating opiate addiction

A novel role for the actin-binding protein drebrin in regulating opiate addiction

The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is...

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Autores principales: Jennifer A. Martin, Craig T. Werner, Swarup Mitra, Ping Zhong, Zi-Jun Wang, Pedro H. Gobira, Andrew. F. Stewart, Jay Zhang, Kyra Erias, Justin N. Siemian, Devin Hagarty, Lauren E. Mueller, Rachael L. Neve, Jun-Xu Li, Ramesh Chandra, Karen C. Dietz, Mary Kay Lobo, Amy M. Gancarz, Zhen Yan, David M. Dietz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fd3986183cd145e696e221b400cee251
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spelling oai:doaj.org-article:fd3986183cd145e696e221b400cee2512021-12-02T17:32:10ZA novel role for the actin-binding protein drebrin in regulating opiate addiction10.1038/s41467-019-12122-82041-1723https://doaj.org/article/fd3986183cd145e696e221b400cee2512019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12122-8https://doaj.org/toc/2041-1723The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient to decrease drug seeking and increase dendritic spine densityJennifer A. MartinCraig T. WernerSwarup MitraPing ZhongZi-Jun WangPedro H. GobiraAndrew. F. StewartJay ZhangKyra EriasJustin N. SiemianDevin HagartyLauren E. MuellerRachael L. NeveJun-Xu LiRamesh ChandraKaren C. DietzMary Kay LoboAmy M. GancarzZhen YanDavid M. DietzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jennifer A. Martin
Craig T. Werner
Swarup Mitra
Ping Zhong
Zi-Jun Wang
Pedro H. Gobira
Andrew. F. Stewart
Jay Zhang
Kyra Erias
Justin N. Siemian
Devin Hagarty
Lauren E. Mueller
Rachael L. Neve
Jun-Xu Li
Ramesh Chandra
Karen C. Dietz
Mary Kay Lobo
Amy M. Gancarz
Zhen Yan
David M. Dietz
A novel role for the actin-binding protein drebrin in regulating opiate addiction
description The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient to decrease drug seeking and increase dendritic spine density
format article
author Jennifer A. Martin
Craig T. Werner
Swarup Mitra
Ping Zhong
Zi-Jun Wang
Pedro H. Gobira
Andrew. F. Stewart
Jay Zhang
Kyra Erias
Justin N. Siemian
Devin Hagarty
Lauren E. Mueller
Rachael L. Neve
Jun-Xu Li
Ramesh Chandra
Karen C. Dietz
Mary Kay Lobo
Amy M. Gancarz
Zhen Yan
David M. Dietz
author_facet Jennifer A. Martin
Craig T. Werner
Swarup Mitra
Ping Zhong
Zi-Jun Wang
Pedro H. Gobira
Andrew. F. Stewart
Jay Zhang
Kyra Erias
Justin N. Siemian
Devin Hagarty
Lauren E. Mueller
Rachael L. Neve
Jun-Xu Li
Ramesh Chandra
Karen C. Dietz
Mary Kay Lobo
Amy M. Gancarz
Zhen Yan
David M. Dietz
author_sort Jennifer A. Martin
title A novel role for the actin-binding protein drebrin in regulating opiate addiction
title_short A novel role for the actin-binding protein drebrin in regulating opiate addiction
title_full A novel role for the actin-binding protein drebrin in regulating opiate addiction
title_fullStr A novel role for the actin-binding protein drebrin in regulating opiate addiction
title_full_unstemmed A novel role for the actin-binding protein drebrin in regulating opiate addiction
title_sort novel role for the actin-binding protein drebrin in regulating opiate addiction
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/fd3986183cd145e696e221b400cee251
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