Enhancement of implant osseointegration by high-frequency low-magnitude loading.

<h4>Background</h4>Mechanical loading is known to play an important role in bone remodelling. This study aimed to evaluate the effect of high- and low-frequency axial loading, applied directly to the implant, on peri-implant bone healing and implant osseointegration.<h4>Methodology...

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Autores principales:	Xiaolei Zhang, Antonia Torcasio, Katleen Vandamme, Toru Ogawa, G Harry van Lenthe, Ignace Naert, Joke Duyck
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd39f9e1eb1c42349c81ab6a594f25d5
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spelling	oai:doaj.org-article:fd39f9e1eb1c42349c81ab6a594f25d52021-11-18T07:12:56ZEnhancement of implant osseointegration by high-frequency low-magnitude loading.1932-620310.1371/journal.pone.0040488https://doaj.org/article/fd39f9e1eb1c42349c81ab6a594f25d52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808172/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Mechanical loading is known to play an important role in bone remodelling. This study aimed to evaluate the effect of high- and low-frequency axial loading, applied directly to the implant, on peri-implant bone healing and implant osseointegration.<h4>Methodology</h4>Titanium implants were bilaterally installed in rat tibiae. For every animal, one implant was loaded (test) while the other one was not (control). The test implants were randomly divided into 8 groups according to 4 loading regimes and 2 experimental periods (1 and 4 weeks). The loaded implants were subject to an axial displacement. Within the high- (HF, 40 Hz) or low-frequency (LF, 8 Hz) loading category, the displacements varied 2-fold and were ranked as low- or high-magnitude (LM, HM), respectively. The strain rate amplitudes were kept constant between the two frequency groups. This resulted in the following 4 loading regimes: 1) HF-LM, 40 Hz-8 µm; 2) HF-HM, 40 Hz-16 µm; 3) LF-LM, 8 Hz-41 µm; 4) LF-HM, 8 Hz-82 µm. The tissue samples were processed for resin embedding and subjected to histological and histomorphometrical analyses. Data were analyzed statistically with the significance set at p<0.05.<h4>Principal findings</h4>After loading for 4 weeks, HF-LM loading (40 Hz-8 µm) induced more bone-to-implant contact (BIC) at the level of the cortex compared to its unloaded control. No significant effect of the four loading regimes on the peri-implant bone fraction (BF) was found in the 2 experimental periods.<h4>Conclusions</h4>The stimulatory effect of immediate implant loading on bone-to-implant contact was only observed in case of high-frequency (40 Hz) low-magnitude (8 µm) loading. The applied load regimes failed to influence the peri-implant bone mass.Xiaolei ZhangAntonia TorcasioKatleen VandammeToru OgawaG Harry van LentheIgnace NaertJoke DuyckPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40488 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaolei Zhang Antonia Torcasio Katleen Vandamme Toru Ogawa G Harry van Lenthe Ignace Naert Joke Duyck Enhancement of implant osseointegration by high-frequency low-magnitude loading.
description	<h4>Background</h4>Mechanical loading is known to play an important role in bone remodelling. This study aimed to evaluate the effect of high- and low-frequency axial loading, applied directly to the implant, on peri-implant bone healing and implant osseointegration.<h4>Methodology</h4>Titanium implants were bilaterally installed in rat tibiae. For every animal, one implant was loaded (test) while the other one was not (control). The test implants were randomly divided into 8 groups according to 4 loading regimes and 2 experimental periods (1 and 4 weeks). The loaded implants were subject to an axial displacement. Within the high- (HF, 40 Hz) or low-frequency (LF, 8 Hz) loading category, the displacements varied 2-fold and were ranked as low- or high-magnitude (LM, HM), respectively. The strain rate amplitudes were kept constant between the two frequency groups. This resulted in the following 4 loading regimes: 1) HF-LM, 40 Hz-8 µm; 2) HF-HM, 40 Hz-16 µm; 3) LF-LM, 8 Hz-41 µm; 4) LF-HM, 8 Hz-82 µm. The tissue samples were processed for resin embedding and subjected to histological and histomorphometrical analyses. Data were analyzed statistically with the significance set at p<0.05.<h4>Principal findings</h4>After loading for 4 weeks, HF-LM loading (40 Hz-8 µm) induced more bone-to-implant contact (BIC) at the level of the cortex compared to its unloaded control. No significant effect of the four loading regimes on the peri-implant bone fraction (BF) was found in the 2 experimental periods.<h4>Conclusions</h4>The stimulatory effect of immediate implant loading on bone-to-implant contact was only observed in case of high-frequency (40 Hz) low-magnitude (8 µm) loading. The applied load regimes failed to influence the peri-implant bone mass.
format	article
author	Xiaolei Zhang Antonia Torcasio Katleen Vandamme Toru Ogawa G Harry van Lenthe Ignace Naert Joke Duyck
author_facet	Xiaolei Zhang Antonia Torcasio Katleen Vandamme Toru Ogawa G Harry van Lenthe Ignace Naert Joke Duyck
author_sort	Xiaolei Zhang
title	Enhancement of implant osseointegration by high-frequency low-magnitude loading.
title_short	Enhancement of implant osseointegration by high-frequency low-magnitude loading.
title_full	Enhancement of implant osseointegration by high-frequency low-magnitude loading.
title_fullStr	Enhancement of implant osseointegration by high-frequency low-magnitude loading.
title_full_unstemmed	Enhancement of implant osseointegration by high-frequency low-magnitude loading.
title_sort	enhancement of implant osseointegration by high-frequency low-magnitude loading.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fd39f9e1eb1c42349c81ab6a594f25d5
work_keys_str_mv	AT xiaoleizhang enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT antoniatorcasio enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT katleenvandamme enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT toruogawa enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT gharryvanlenthe enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT ignacenaert enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading AT jokeduyck enhancementofimplantosseointegrationbyhighfrequencylowmagnitudeloading
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Enhancement of implant osseointegration by high-frequency low-magnitude loading.

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