A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities
Abstract Laboratory data interpretation for the assessment of complex biological systems remains a great challenge, as occurs in mitochondrial function research studies. The classical biochemical data interpretation of patients versus reference values may be insufficient, and in fact the current cla...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fd3a1528e8f1420db29f691713d4ac02 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fd3a1528e8f1420db29f691713d4ac02 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fd3a1528e8f1420db29f691713d4ac022021-12-02T12:32:21ZA statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities10.1038/s41598-016-0008-12045-2322https://doaj.org/article/fd3a1528e8f1420db29f691713d4ac022016-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-016-0008-1https://doaj.org/toc/2045-2322Abstract Laboratory data interpretation for the assessment of complex biological systems remains a great challenge, as occurs in mitochondrial function research studies. The classical biochemical data interpretation of patients versus reference values may be insufficient, and in fact the current classifications of mitochondrial patients are still done on basis of probability criteria. We have developed and applied a mathematic agglomerative algorithm to search for correlations among the different biochemical variables of the mitochondrial respiratory chain in order to identify populations displaying correlation coefficients >0.95. We demonstrated that coenzyme Q10 may be a better biomarker of mitochondrial respiratory chain enzyme activities than the citrate synthase activity. Furthermore, the application of this algorithm may be useful to re-classify mitochondrial patients or to explore associations among other biochemical variables from different biological systems.D. YuberoA. AdinR. MonteroC. JouC. Jiménez-MallebreraA. García-CazorlaA. NascimentoM. M. O’CallaghanJ. MontoyaL. GortP. NavasA. RibesM. D. UgarteR. ArtuchNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 6, Iss 1, Pp 1-7 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q D. Yubero A. Adin R. Montero C. Jou C. Jiménez-Mallebrera A. García-Cazorla A. Nascimento M. M. O’Callaghan J. Montoya L. Gort P. Navas A. Ribes M. D. Ugarte R. Artuch A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| description |
Abstract Laboratory data interpretation for the assessment of complex biological systems remains a great challenge, as occurs in mitochondrial function research studies. The classical biochemical data interpretation of patients versus reference values may be insufficient, and in fact the current classifications of mitochondrial patients are still done on basis of probability criteria. We have developed and applied a mathematic agglomerative algorithm to search for correlations among the different biochemical variables of the mitochondrial respiratory chain in order to identify populations displaying correlation coefficients >0.95. We demonstrated that coenzyme Q10 may be a better biomarker of mitochondrial respiratory chain enzyme activities than the citrate synthase activity. Furthermore, the application of this algorithm may be useful to re-classify mitochondrial patients or to explore associations among other biochemical variables from different biological systems. |
| format |
article |
| author |
D. Yubero A. Adin R. Montero C. Jou C. Jiménez-Mallebrera A. García-Cazorla A. Nascimento M. M. O’Callaghan J. Montoya L. Gort P. Navas A. Ribes M. D. Ugarte R. Artuch |
| author_facet |
D. Yubero A. Adin R. Montero C. Jou C. Jiménez-Mallebrera A. García-Cazorla A. Nascimento M. M. O’Callaghan J. Montoya L. Gort P. Navas A. Ribes M. D. Ugarte R. Artuch |
| author_sort |
D. Yubero |
| title |
A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| title_short |
A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| title_full |
A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| title_fullStr |
A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| title_full_unstemmed |
A statistical algorithm showing coenzyme Q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| title_sort |
statistical algorithm showing coenzyme q10 and citrate synthase as biomarkers for mitochondrial respiratory chain enzyme activities |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/fd3a1528e8f1420db29f691713d4ac02 |
| work_keys_str_mv |
AT dyubero astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT aadin astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT rmontero astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT cjou astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT cjimenezmallebrera astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT agarciacazorla astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT anascimento astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT mmocallaghan astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT jmontoya astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT lgort astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT pnavas astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT aribes astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT mdugarte astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT rartuch astatisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT dyubero statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT aadin statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT rmontero statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT cjou statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT cjimenezmallebrera statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT agarciacazorla statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT anascimento statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT mmocallaghan statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT jmontoya statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT lgort statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT pnavas statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT aribes statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT mdugarte statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities AT rartuch statisticalalgorithmshowingcoenzymeq10andcitratesynthaseasbiomarkersformitochondrialrespiratorychainenzymeactivities |
| _version_ |
1718394134462464000 |