The induction and function of the anti-inflammatory fate of TH17 cells

The induction and function of the anti-inflammatory fate of TH17 cells

CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simulta...

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Autores principales: Hao Xu, Theodora Agalioti, Jun Zhao, Babett Steglich, Ramez Wahib, Maria Carolina Amezcua Vesely, Piotr Bielecki, Will Bailis, Ruaidhri Jackson, Daniel Perez, Jakob Izbicki, Paula Licona-Limón, Vesa Kaartinen, Jens Geginat, Enric Esplugues, Eva Tolosa, Samuel Huber, Richard A. Flavell, Nicola Gagliani
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/fd3bdc3cbb8644b4bdee048b5254c9a1
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spelling oai:doaj.org-article:fd3bdc3cbb8644b4bdee048b5254c9a12021-12-02T14:34:13ZThe induction and function of the anti-inflammatory fate of TH17 cells10.1038/s41467-020-17097-52041-1723https://doaj.org/article/fd3bdc3cbb8644b4bdee048b5254c9a12020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17097-5https://doaj.org/toc/2041-1723CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simultaneously dampens protective immunity against S. aureus.Hao XuTheodora AgaliotiJun ZhaoBabett SteglichRamez WahibMaria Carolina Amezcua VeselyPiotr BieleckiWill BailisRuaidhri JacksonDaniel PerezJakob IzbickiPaula Licona-LimónVesa KaartinenJens GeginatEnric EspluguesEva TolosaSamuel HuberRichard A. FlavellNicola GaglianiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hao Xu
Theodora Agalioti
Jun Zhao
Babett Steglich
Ramez Wahib
Maria Carolina Amezcua Vesely
Piotr Bielecki
Will Bailis
Ruaidhri Jackson
Daniel Perez
Jakob Izbicki
Paula Licona-Limón
Vesa Kaartinen
Jens Geginat
Enric Esplugues
Eva Tolosa
Samuel Huber
Richard A. Flavell
Nicola Gagliani
The induction and function of the anti-inflammatory fate of TH17 cells
description CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simultaneously dampens protective immunity against S. aureus.
format article
author Hao Xu
Theodora Agalioti
Jun Zhao
Babett Steglich
Ramez Wahib
Maria Carolina Amezcua Vesely
Piotr Bielecki
Will Bailis
Ruaidhri Jackson
Daniel Perez
Jakob Izbicki
Paula Licona-Limón
Vesa Kaartinen
Jens Geginat
Enric Esplugues
Eva Tolosa
Samuel Huber
Richard A. Flavell
Nicola Gagliani
author_facet Hao Xu
Theodora Agalioti
Jun Zhao
Babett Steglich
Ramez Wahib
Maria Carolina Amezcua Vesely
Piotr Bielecki
Will Bailis
Ruaidhri Jackson
Daniel Perez
Jakob Izbicki
Paula Licona-Limón
Vesa Kaartinen
Jens Geginat
Enric Esplugues
Eva Tolosa
Samuel Huber
Richard A. Flavell
Nicola Gagliani
author_sort Hao Xu
title The induction and function of the anti-inflammatory fate of TH17 cells
title_short The induction and function of the anti-inflammatory fate of TH17 cells
title_full The induction and function of the anti-inflammatory fate of TH17 cells
title_fullStr The induction and function of the anti-inflammatory fate of TH17 cells
title_full_unstemmed The induction and function of the anti-inflammatory fate of TH17 cells
title_sort induction and function of the anti-inflammatory fate of th17 cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/fd3bdc3cbb8644b4bdee048b5254c9a1
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