Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Myeloid-derived suppressive cells (MDSCs) promote metastasis. Here, the authors show that the monocytic MDSCs subset promotes epithelial to mesenchymal transition at the primary site while the granulocytic subset promotes the reverse transition at the metastatic site enabling dynamic tumour cells pl...

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Autores principales:	Maria Ouzounova, Eunmi Lee, Raziye Piranlioglu, Abdeljabar El Andaloussi, Ravindra Kolhe, Mehmet F. Demirci, Daniela Marasco, Iskander Asm, Ahmed Chadli, Khaled A. Hassan, Muthusamy Thangaraju, Gang Zhou, Ali S. Arbab, John K. Cowell, Hasan Korkaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd3befe0433a4fdaa9773cbb10f54358
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spelling	oai:doaj.org-article:fd3befe0433a4fdaa9773cbb10f543582021-12-02T14:42:03ZMonocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade10.1038/ncomms149792041-1723https://doaj.org/article/fd3befe0433a4fdaa9773cbb10f543582017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14979https://doaj.org/toc/2041-1723Myeloid-derived suppressive cells (MDSCs) promote metastasis. Here, the authors show that the monocytic MDSCs subset promotes epithelial to mesenchymal transition at the primary site while the granulocytic subset promotes the reverse transition at the metastatic site enabling dynamic tumour cells plasticity.Maria OuzounovaEunmi LeeRaziye PiranliogluAbdeljabar El AndaloussiRavindra KolheMehmet F. DemirciDaniela MarascoIskander AsmAhmed ChadliKhaled A. HassanMuthusamy ThangarajuGang ZhouAli S. ArbabJohn K. CowellHasan KorkayaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Ouzounova Eunmi Lee Raziye Piranlioglu Abdeljabar El Andaloussi Ravindra Kolhe Mehmet F. Demirci Daniela Marasco Iskander Asm Ahmed Chadli Khaled A. Hassan Muthusamy Thangaraju Gang Zhou Ali S. Arbab John K. Cowell Hasan Korkaya Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
description	Myeloid-derived suppressive cells (MDSCs) promote metastasis. Here, the authors show that the monocytic MDSCs subset promotes epithelial to mesenchymal transition at the primary site while the granulocytic subset promotes the reverse transition at the metastatic site enabling dynamic tumour cells plasticity.
format	article
author	Maria Ouzounova Eunmi Lee Raziye Piranlioglu Abdeljabar El Andaloussi Ravindra Kolhe Mehmet F. Demirci Daniela Marasco Iskander Asm Ahmed Chadli Khaled A. Hassan Muthusamy Thangaraju Gang Zhou Ali S. Arbab John K. Cowell Hasan Korkaya
author_facet	Maria Ouzounova Eunmi Lee Raziye Piranlioglu Abdeljabar El Andaloussi Ravindra Kolhe Mehmet F. Demirci Daniela Marasco Iskander Asm Ahmed Chadli Khaled A. Hassan Muthusamy Thangaraju Gang Zhou Ali S. Arbab John K. Cowell Hasan Korkaya
author_sort	Maria Ouzounova
title	Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
title_short	Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
title_full	Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
title_fullStr	Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
title_full_unstemmed	Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
title_sort	monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fd3befe0433a4fdaa9773cbb10f54358
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Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

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