Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks

Abstract The rheological and physiological properties of red blood cells (RBCs) are affected by many factors in the vascular environment. Among them, membrane fluctuations (MFs), particularly dynamic fluctuations in RBC cell membrane thickness (RBC-MFs), are likely to be altered by the level of glyc...

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Autores principales:	Minji Sohn, Ji Eun Lee, MinGeun Ahn, YongKeun Park, Soo Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd3fdd7fab754ae1ad2192f579da31b9
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spelling	oai:doaj.org-article:fd3fdd7fab754ae1ad2192f579da31b92021-12-02T11:45:00ZCorrelation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks10.1038/s41598-021-86528-02045-2322https://doaj.org/article/fd3fdd7fab754ae1ad2192f579da31b92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86528-0https://doaj.org/toc/2045-2322Abstract The rheological and physiological properties of red blood cells (RBCs) are affected by many factors in the vascular environment. Among them, membrane fluctuations (MFs), particularly dynamic fluctuations in RBC cell membrane thickness (RBC-MFs), are likely to be altered by the level of glycation of haemoglobin in patients with diabetes mellitus (DM). We investigated the associations of RBC-MFs with physiological variables associated with DM and cardiovascular diseases (CVDs). Forty-one healthy control subjects and 59 patients with DM were enrolled. Five-microliter samples of blood were collected and diluted 400 times. To measure the RBC-MFs, holotomography was used, which non-invasively and precisely analyses the optical characteristics of RBCs. Associations between the RBC-MFs and biochemical parameters related to glucose homeostasis and lipid profiles were investigated. Independent associations of the RBC-MFs with the presence of CVDs were also analysed. RBC-MFs were lower in patients with DM than in healthy participants (61.64 ± 7.49 nm vs 70.65 ± 6.65 nm, P = 1.4 × 10−8). RBC-MFs correlated modestly with glycated haemoglobin level (ρ = − 0.47) and weakly with age (ρ = − 0.36), duration of diabetes (ρ = − 0.36), fasting plasma glucose level (ρ = − 0.37), and the 10-year Framingham risk score (ρ = − 0.38) (all P < 0.05). Low RBC-MFs were independently associated with the presence of CVDs after adjusting for CVD risk factors. The weak but significant associations of RBC-MFs with cardiometabolic risk factors and CVDs suggest that such deformity of circulating RBCs may be a useful marker of vascular complications of DM.Minji SohnJi Eun LeeMinGeun AhnYongKeun ParkSoo LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minji Sohn Ji Eun Lee MinGeun Ahn YongKeun Park Soo Lim Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
description	Abstract The rheological and physiological properties of red blood cells (RBCs) are affected by many factors in the vascular environment. Among them, membrane fluctuations (MFs), particularly dynamic fluctuations in RBC cell membrane thickness (RBC-MFs), are likely to be altered by the level of glycation of haemoglobin in patients with diabetes mellitus (DM). We investigated the associations of RBC-MFs with physiological variables associated with DM and cardiovascular diseases (CVDs). Forty-one healthy control subjects and 59 patients with DM were enrolled. Five-microliter samples of blood were collected and diluted 400 times. To measure the RBC-MFs, holotomography was used, which non-invasively and precisely analyses the optical characteristics of RBCs. Associations between the RBC-MFs and biochemical parameters related to glucose homeostasis and lipid profiles were investigated. Independent associations of the RBC-MFs with the presence of CVDs were also analysed. RBC-MFs were lower in patients with DM than in healthy participants (61.64 ± 7.49 nm vs 70.65 ± 6.65 nm, P = 1.4 × 10−8). RBC-MFs correlated modestly with glycated haemoglobin level (ρ = − 0.47) and weakly with age (ρ = − 0.36), duration of diabetes (ρ = − 0.36), fasting plasma glucose level (ρ = − 0.37), and the 10-year Framingham risk score (ρ = − 0.38) (all P < 0.05). Low RBC-MFs were independently associated with the presence of CVDs after adjusting for CVD risk factors. The weak but significant associations of RBC-MFs with cardiometabolic risk factors and CVDs suggest that such deformity of circulating RBCs may be a useful marker of vascular complications of DM.
format	article
author	Minji Sohn Ji Eun Lee MinGeun Ahn YongKeun Park Soo Lim
author_facet	Minji Sohn Ji Eun Lee MinGeun Ahn YongKeun Park Soo Lim
author_sort	Minji Sohn
title	Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
title_short	Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
title_full	Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
title_fullStr	Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
title_full_unstemmed	Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
title_sort	correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd3fdd7fab754ae1ad2192f579da31b9
work_keys_str_mv	AT minjisohn correlationofdynamicmembranefluctuationsinredbloodcellswithdiabetesmellitusandcardiovascularrisks AT jieunlee correlationofdynamicmembranefluctuationsinredbloodcellswithdiabetesmellitusandcardiovascularrisks AT mingeunahn correlationofdynamicmembranefluctuationsinredbloodcellswithdiabetesmellitusandcardiovascularrisks AT yongkeunpark correlationofdynamicmembranefluctuationsinredbloodcellswithdiabetesmellitusandcardiovascularrisks AT soolim correlationofdynamicmembranefluctuationsinredbloodcellswithdiabetesmellitusandcardiovascularrisks
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Correlation of dynamic membrane fluctuations in red blood cells with diabetes mellitus and cardiovascular risks

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