Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19

Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in patients with respiratory infection, but their safety in coronavirus disease 19 (Covid-19) patients has not been fully investigated. We evaluated an association between NSAID use and outcomes of Covid-19. This study was...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jungchan Park, Seung-Hwa Lee, Seng Chan You, Jinseob Kim, Kwangmo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd407c645d214a0093de62962cf4f3ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd407c645d214a0093de62962cf4f3ee
record_format	dspace
spelling	oai:doaj.org-article:fd407c645d214a0093de62962cf4f3ee2021-12-02T13:19:21ZNon-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 1910.1038/s41598-021-84539-52045-2322https://doaj.org/article/fd407c645d214a0093de62962cf4f3ee2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84539-5https://doaj.org/toc/2045-2322Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in patients with respiratory infection, but their safety in coronavirus disease 19 (Covid-19) patients has not been fully investigated. We evaluated an association between NSAID use and outcomes of Covid-19. This study was a retrospective observational cohort study based on insurance benefit claims sent to the Health Insurance Review and Assessment Service of Korea by May 15, 2020. These claims comprised all Covid-19-tested cases and history of medical service use for the past 3 years in these patients. The primary outcome was all-cause mortality, and the secondary outcome was need for ventilator care. Among 7590 patients diagnosed with Covid-19, two distinct cohorts were generated based on NSAID or acetaminophen prescription within 2 weeks before Covid-19 diagnosis. A total of 398 patients was prescribed NSAIDs, and 2365 patients were prescribed acetaminophen. After propensity score matching, 397 pairs of data set were generated, and all-cause mortality of the NSAIDs group showed no significant difference compared with the acetaminophen group (4.0% vs. 3.0%; hazard ratio [HR], 1.33; 95% confidence interval [CI], 0.63–2.88; P = 0.46). The rate of ventilator care also did not show significantly different results between the two groups (2.0% vs. 1.3%; HR, 1.60; 95% CI 0.53–5.30; P = 0.42). Use of NSAIDs was not associated with mortality or ventilator care in Covid-19 patients. NSAIDs may be safely used to relieve symptoms in patients with suspicion of Covid-19.Jungchan ParkSeung-Hwa LeeSeng Chan YouJinseob KimKwangmo YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jungchan Park Seung-Hwa Lee Seng Chan You Jinseob Kim Kwangmo Yang Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
description	Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in patients with respiratory infection, but their safety in coronavirus disease 19 (Covid-19) patients has not been fully investigated. We evaluated an association between NSAID use and outcomes of Covid-19. This study was a retrospective observational cohort study based on insurance benefit claims sent to the Health Insurance Review and Assessment Service of Korea by May 15, 2020. These claims comprised all Covid-19-tested cases and history of medical service use for the past 3 years in these patients. The primary outcome was all-cause mortality, and the secondary outcome was need for ventilator care. Among 7590 patients diagnosed with Covid-19, two distinct cohorts were generated based on NSAID or acetaminophen prescription within 2 weeks before Covid-19 diagnosis. A total of 398 patients was prescribed NSAIDs, and 2365 patients were prescribed acetaminophen. After propensity score matching, 397 pairs of data set were generated, and all-cause mortality of the NSAIDs group showed no significant difference compared with the acetaminophen group (4.0% vs. 3.0%; hazard ratio [HR], 1.33; 95% confidence interval [CI], 0.63–2.88; P = 0.46). The rate of ventilator care also did not show significantly different results between the two groups (2.0% vs. 1.3%; HR, 1.60; 95% CI 0.53–5.30; P = 0.42). Use of NSAIDs was not associated with mortality or ventilator care in Covid-19 patients. NSAIDs may be safely used to relieve symptoms in patients with suspicion of Covid-19.
format	article
author	Jungchan Park Seung-Hwa Lee Seng Chan You Jinseob Kim Kwangmo Yang
author_facet	Jungchan Park Seung-Hwa Lee Seng Chan You Jinseob Kim Kwangmo Yang
author_sort	Jungchan Park
title	Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
title_short	Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
title_full	Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
title_fullStr	Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
title_full_unstemmed	Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
title_sort	non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd407c645d214a0093de62962cf4f3ee
work_keys_str_mv	AT jungchanpark nonsteroidalantiinflammatoryagentusemaynotbeassociatedwithmortalityofcoronavirusdisease19 AT seunghwalee nonsteroidalantiinflammatoryagentusemaynotbeassociatedwithmortalityofcoronavirusdisease19 AT sengchanyou nonsteroidalantiinflammatoryagentusemaynotbeassociatedwithmortalityofcoronavirusdisease19 AT jinseobkim nonsteroidalantiinflammatoryagentusemaynotbeassociatedwithmortalityofcoronavirusdisease19 AT kwangmoyang nonsteroidalantiinflammatoryagentusemaynotbeassociatedwithmortalityofcoronavirusdisease19
_version_	1718393309245734912

Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19

Ejemplares similares