Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.

Mycoplasma (M.) bovis is frequently implicated in respiratory diseases of young cattle worldwide. Today, to combat M. bovis in Europe, only antimicrobial therapy is available, but often fails, leading to important economical losses. The antimicrobial susceptibility of M. bovis is not covered by anti...

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Autores principales:	Anne V Gautier-Bouchardon, Séverine Ferré, Dominique Le Grand, Agnès Paoli, Emilie Gay, François Poumarat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd4455b1356f49ffa2c5828950e5e7f8
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spelling	oai:doaj.org-article:fd4455b1356f49ffa2c5828950e5e7f82021-11-18T08:34:01ZOverall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.1932-620310.1371/journal.pone.0087672https://doaj.org/article/fd4455b1356f49ffa2c5828950e5e7f82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24503775/?tool=EBIhttps://doaj.org/toc/1932-6203Mycoplasma (M.) bovis is frequently implicated in respiratory diseases of young cattle worldwide. Today, to combat M. bovis in Europe, only antimicrobial therapy is available, but often fails, leading to important economical losses. The antimicrobial susceptibility of M. bovis is not covered by antimicrobial resistance surveillance networks. The objectives of this study were to identify resistances that were acquired over the last 30 years in France and to determine their prevalence within contemporary strains. The minimum inhibition concentration (MIC) values of 12 antimicrobials, considered active on M. bovis, were compared, using an agar dilution method, between 27 and 46 M. bovis isolates respectively obtained in 1978-1979 and in 2010-2012 from 73 distinct respiratory disease outbreaks in young cattle all over France. For eight antimicrobials, resistances were proven to be acquired over the period and expressed by all contemporary strains. The increase of the MIC value that inhibited 50% of the isolates (MIC50) was: i) substantial for tylosin, tilmicosin, tulathromycin and spectinomycin, from 2 to >64, 2 to >128, 16 to 128 and 4 to >64 µg/mL, respectively, ii) moderate for enrofloxacin, danofloxacin, marbofloxacin and oxytetracycline, from 0.25 to 0.5, 0.25 to 0.5, 0.5 to 1, 32 to >32 µg/mL, respectively. No differences were observed for gamithromycin, tildipirosin, florfenicol and valnemulin with MIC50 of 128, 128, 8, <0.03 µg/mL, respectively. If referring to breakpoint MIC values published for respiratory bovine pathogens, all contemporary isolates would be intermediate in vivo for fluoroquinolones and resistant to macrolides, oxytetracycline, spectinomycin and florfenicol.Anne V Gautier-BouchardonSéverine FerréDominique Le GrandAgnès PaoliEmilie GayFrançois PoumaratPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87672 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne V Gautier-Bouchardon Séverine Ferré Dominique Le Grand Agnès Paoli Emilie Gay François Poumarat Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
description	Mycoplasma (M.) bovis is frequently implicated in respiratory diseases of young cattle worldwide. Today, to combat M. bovis in Europe, only antimicrobial therapy is available, but often fails, leading to important economical losses. The antimicrobial susceptibility of M. bovis is not covered by antimicrobial resistance surveillance networks. The objectives of this study were to identify resistances that were acquired over the last 30 years in France and to determine their prevalence within contemporary strains. The minimum inhibition concentration (MIC) values of 12 antimicrobials, considered active on M. bovis, were compared, using an agar dilution method, between 27 and 46 M. bovis isolates respectively obtained in 1978-1979 and in 2010-2012 from 73 distinct respiratory disease outbreaks in young cattle all over France. For eight antimicrobials, resistances were proven to be acquired over the period and expressed by all contemporary strains. The increase of the MIC value that inhibited 50% of the isolates (MIC50) was: i) substantial for tylosin, tilmicosin, tulathromycin and spectinomycin, from 2 to >64, 2 to >128, 16 to 128 and 4 to >64 µg/mL, respectively, ii) moderate for enrofloxacin, danofloxacin, marbofloxacin and oxytetracycline, from 0.25 to 0.5, 0.25 to 0.5, 0.5 to 1, 32 to >32 µg/mL, respectively. No differences were observed for gamithromycin, tildipirosin, florfenicol and valnemulin with MIC50 of 128, 128, 8, <0.03 µg/mL, respectively. If referring to breakpoint MIC values published for respiratory bovine pathogens, all contemporary isolates would be intermediate in vivo for fluoroquinolones and resistant to macrolides, oxytetracycline, spectinomycin and florfenicol.
format	article
author	Anne V Gautier-Bouchardon Séverine Ferré Dominique Le Grand Agnès Paoli Emilie Gay François Poumarat
author_facet	Anne V Gautier-Bouchardon Séverine Ferré Dominique Le Grand Agnès Paoli Emilie Gay François Poumarat
author_sort	Anne V Gautier-Bouchardon
title	Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
title_short	Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
title_full	Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
title_fullStr	Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
title_full_unstemmed	Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.
title_sort	overall decrease in the susceptibility of mycoplasma bovis to antimicrobials over the past 30 years in france.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fd4455b1356f49ffa2c5828950e5e7f8
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Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France.

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