Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia

Abstract Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the re...

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Autores principales:	Marisol Herrera-Rivero, Rong Zhang, Stefanie Heilmann-Heimbach, Andreas Mueller, Soyhan Bagci, Till Dresbach, Lukas Schröder, Stefan Holdenrieder, Heiko M. Reutter, Florian Kipfmueller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd4540ecc3ac4b41ad9fdb8859636c70
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spelling	oai:doaj.org-article:fd4540ecc3ac4b41ad9fdb8859636c702021-12-02T11:40:26ZCirculating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia10.1038/s41598-018-29153-82045-2322https://doaj.org/article/fd4540ecc3ac4b41ad9fdb8859636c702018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29153-8https://doaj.org/toc/2045-2322Abstract Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the results from an expression profiling of circulating microRNAs (miRNAs) in direct post-pulmonary blood flow of 18 CDH newborns. Seven miRNAs differentially expressed in children that either died or developed chronic lung disease (CLD) up to 28 days after birth, compared to those who survived without developing CLD during this period, were identified. Target gene and pathway analyses indicate that these miRNAs functions include regulation of the cell cycle, inflammation and morphogenesis, by targeting molecules responsive to growth factors, cytokines and cellular stressors. Furthermore, we identified hub molecules by constructing a protein-protein interaction network of shared targets, and ranked the relative importance of the identified miRNAs. Our results suggest that dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature, compromise cardiac function and contribute to the development of CLD in CDH. Further investigation of the biomarker and therapeutic potential of these circulating miRNAs is encouraged.Marisol Herrera-RiveroRong ZhangStefanie Heilmann-HeimbachAndreas MuellerSoyhan BagciTill DresbachLukas SchröderStefan HoldenriederHeiko M. ReutterFlorian KipfmuellerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marisol Herrera-Rivero Rong Zhang Stefanie Heilmann-Heimbach Andreas Mueller Soyhan Bagci Till Dresbach Lukas Schröder Stefan Holdenrieder Heiko M. Reutter Florian Kipfmueller Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
description	Abstract Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the results from an expression profiling of circulating microRNAs (miRNAs) in direct post-pulmonary blood flow of 18 CDH newborns. Seven miRNAs differentially expressed in children that either died or developed chronic lung disease (CLD) up to 28 days after birth, compared to those who survived without developing CLD during this period, were identified. Target gene and pathway analyses indicate that these miRNAs functions include regulation of the cell cycle, inflammation and morphogenesis, by targeting molecules responsive to growth factors, cytokines and cellular stressors. Furthermore, we identified hub molecules by constructing a protein-protein interaction network of shared targets, and ranked the relative importance of the identified miRNAs. Our results suggest that dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature, compromise cardiac function and contribute to the development of CLD in CDH. Further investigation of the biomarker and therapeutic potential of these circulating miRNAs is encouraged.
format	article
author	Marisol Herrera-Rivero Rong Zhang Stefanie Heilmann-Heimbach Andreas Mueller Soyhan Bagci Till Dresbach Lukas Schröder Stefan Holdenrieder Heiko M. Reutter Florian Kipfmueller
author_facet	Marisol Herrera-Rivero Rong Zhang Stefanie Heilmann-Heimbach Andreas Mueller Soyhan Bagci Till Dresbach Lukas Schröder Stefan Holdenrieder Heiko M. Reutter Florian Kipfmueller
author_sort	Marisol Herrera-Rivero
title	Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
title_short	Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
title_full	Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
title_fullStr	Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
title_full_unstemmed	Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia
title_sort	circulating micrornas are associated with pulmonary hypertension and development of chronic lung disease in congenital diaphragmatic hernia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fd4540ecc3ac4b41ad9fdb8859636c70
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Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia

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