Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

The efficacy of stimuli-responsive enzyme delivery systems is usually limited to in vitro applications. Here the authors form artificial organelles by inserting stimuli-responsive protein gates in membranes of polymersomes loaded with enzymes and obtain a triggered functionality both in vitro and in...

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Autores principales:	T. Einfalt, D. Witzigmann, C. Edlinger, S. Sieber, R. Goers, A. Najer, M. Spulber, O. Onaca-Fischer, J. Huwyler, C. G. Palivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd48b4028b1543f0b1df3998fb2b1d1c
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spelling	oai:doaj.org-article:fd48b4028b1543f0b1df3998fb2b1d1c2021-12-02T17:33:15ZBiomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment10.1038/s41467-018-03560-x2041-1723https://doaj.org/article/fd48b4028b1543f0b1df3998fb2b1d1c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03560-xhttps://doaj.org/toc/2041-1723The efficacy of stimuli-responsive enzyme delivery systems is usually limited to in vitro applications. Here the authors form artificial organelles by inserting stimuli-responsive protein gates in membranes of polymersomes loaded with enzymes and obtain a triggered functionality both in vitro and in vivo.T. EinfaltD. WitzigmannC. EdlingerS. SieberR. GoersA. NajerM. SpulberO. Onaca-FischerJ. HuwylerC. G. PalivanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q T. Einfalt D. Witzigmann C. Edlinger S. Sieber R. Goers A. Najer M. Spulber O. Onaca-Fischer J. Huwyler C. G. Palivan Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
description	The efficacy of stimuli-responsive enzyme delivery systems is usually limited to in vitro applications. Here the authors form artificial organelles by inserting stimuli-responsive protein gates in membranes of polymersomes loaded with enzymes and obtain a triggered functionality both in vitro and in vivo.
format	article
author	T. Einfalt D. Witzigmann C. Edlinger S. Sieber R. Goers A. Najer M. Spulber O. Onaca-Fischer J. Huwyler C. G. Palivan
author_facet	T. Einfalt D. Witzigmann C. Edlinger S. Sieber R. Goers A. Najer M. Spulber O. Onaca-Fischer J. Huwyler C. G. Palivan
author_sort	T. Einfalt
title	Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
title_short	Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
title_full	Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
title_fullStr	Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
title_full_unstemmed	Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
title_sort	biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fd48b4028b1543f0b1df3998fb2b1d1c
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Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

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