Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children

This study aimed to investigate the short-term effect of exposure to indoor fine particulate matter (PM<sub>2.5</sub>) on atopic dermatitis (AD) symptoms in children. Sixty-four children (40 boys and 24 girls) with moderate-to-severe AD, aged under 18 years were enrolled in the study. Th...

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Autores principales:	Young-Min Kim, Jihyun Kim, Seoung-Chul Ha, Kangmo Ahn
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fine particulate matters atopic dermatitis children indoor season Medicine R
Acceso en línea:	https://doaj.org/article/fd5034cf7efc417986199e08a7513a54
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spelling	oai:doaj.org-article:fd5034cf7efc417986199e08a7513a542021-11-11T16:37:52ZEffects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children10.3390/ijerph1821115091660-46011661-7827https://doaj.org/article/fd5034cf7efc417986199e08a7513a542021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11509https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601This study aimed to investigate the short-term effect of exposure to indoor fine particulate matter (PM<sub>2.5</sub>) on atopic dermatitis (AD) symptoms in children. Sixty-four children (40 boys and 24 girls) with moderate-to-severe AD, aged under 18 years were enrolled in the study. They were followed up from February 2019 through November 2020. Exposure to indoor PM<sub>2.5</sub> in each household of the enrolled children and their AD symptoms were measured daily. The generalized linear mixed model was utilized for statistical analysis. Subdivision analysis was performed by stratifying the patients by age, sex, season, severity, the presence of family allergic diseases, sensitization, and indoor environment conditions including temperature and relative humidity. A total of 9,321 person-days of AD symptom data were collected. The average PM<sub>2.5</sub> concentration was 28.7 ± 24.3 µg/m<sup>3</sup>, with the highest value in winter (47.1 ± 29.6 µg/m<sup>3</sup>). The overall effect of PM<sub>2.5</sub> on AD symptoms was not statistically significant. However, an increase of 10 µg/m<sup>3</sup> in indoor PM<sub>2.5</sub> concentration increased AD symptom scores by 16.5% (95% CI: 6.5, 27.5) in spring and12.6% (95% CI: 4.3, 21.5) in winter, 6.7% (95% CI: 2.3, 11.3) at indoor temperatures of <25.5 °C, and by 15.0% (95% CI: 3.5, 27.7) with no use of an air purifier. The harmful effect of PM<sub>2.5</sub> in boys, in children aged ≥6 years, and in children with inhalant allergen sensitization was significant, showing an increase in AD symptoms of 4.9% (95% CI: 1.4, 8.6), 12.0% (95% CI: 5.3, 19.1), and 7.0% (95% CI: 1.9, 12.3) per 10 µg/m<sup>3</sup> of PM<sub>2.5</sub>, respectively. Furthermore, children with inhalant allergen sensitization plus severe symptoms (SCORing Atopic Dermatitis, SCORAD ≥ 30.7, median value) showed more harmful effects from exposure to PM<sub>2.5</sub> (15.7% (95% CI: 4.5, 28.1) increase in AD symptom scores per 10 µg/m<sup>3</sup> of PM<sub>2.5</sub> increase). Indoor exposure to PM<sub>2.5</sub> exacerbated AD symptoms in children in spring, winter, and at indoor temperatures of < 25.5 °C. In particular, this harmful effect was prominent in children with inhalant allergen sensitization and severe symptoms. Minimizing exposure to indoor PM<sub>2.5</sub> is needed for the proper management of AD.Young-Min KimJihyun KimSeoung-Chul HaKangmo AhnMDPI AGarticlefine particulate mattersatopic dermatitischildrenindoorseasonMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11509, p 11509 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fine particulate matters atopic dermatitis children indoor season Medicine R
spellingShingle	fine particulate matters atopic dermatitis children indoor season Medicine R Young-Min Kim Jihyun Kim Seoung-Chul Ha Kangmo Ahn Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
description	This study aimed to investigate the short-term effect of exposure to indoor fine particulate matter (PM<sub>2.5</sub>) on atopic dermatitis (AD) symptoms in children. Sixty-four children (40 boys and 24 girls) with moderate-to-severe AD, aged under 18 years were enrolled in the study. They were followed up from February 2019 through November 2020. Exposure to indoor PM<sub>2.5</sub> in each household of the enrolled children and their AD symptoms were measured daily. The generalized linear mixed model was utilized for statistical analysis. Subdivision analysis was performed by stratifying the patients by age, sex, season, severity, the presence of family allergic diseases, sensitization, and indoor environment conditions including temperature and relative humidity. A total of 9,321 person-days of AD symptom data were collected. The average PM<sub>2.5</sub> concentration was 28.7 ± 24.3 µg/m<sup>3</sup>, with the highest value in winter (47.1 ± 29.6 µg/m<sup>3</sup>). The overall effect of PM<sub>2.5</sub> on AD symptoms was not statistically significant. However, an increase of 10 µg/m<sup>3</sup> in indoor PM<sub>2.5</sub> concentration increased AD symptom scores by 16.5% (95% CI: 6.5, 27.5) in spring and12.6% (95% CI: 4.3, 21.5) in winter, 6.7% (95% CI: 2.3, 11.3) at indoor temperatures of <25.5 °C, and by 15.0% (95% CI: 3.5, 27.7) with no use of an air purifier. The harmful effect of PM<sub>2.5</sub> in boys, in children aged ≥6 years, and in children with inhalant allergen sensitization was significant, showing an increase in AD symptoms of 4.9% (95% CI: 1.4, 8.6), 12.0% (95% CI: 5.3, 19.1), and 7.0% (95% CI: 1.9, 12.3) per 10 µg/m<sup>3</sup> of PM<sub>2.5</sub>, respectively. Furthermore, children with inhalant allergen sensitization plus severe symptoms (SCORing Atopic Dermatitis, SCORAD ≥ 30.7, median value) showed more harmful effects from exposure to PM<sub>2.5</sub> (15.7% (95% CI: 4.5, 28.1) increase in AD symptom scores per 10 µg/m<sup>3</sup> of PM<sub>2.5</sub> increase). Indoor exposure to PM<sub>2.5</sub> exacerbated AD symptoms in children in spring, winter, and at indoor temperatures of < 25.5 °C. In particular, this harmful effect was prominent in children with inhalant allergen sensitization and severe symptoms. Minimizing exposure to indoor PM<sub>2.5</sub> is needed for the proper management of AD.
format	article
author	Young-Min Kim Jihyun Kim Seoung-Chul Ha Kangmo Ahn
author_facet	Young-Min Kim Jihyun Kim Seoung-Chul Ha Kangmo Ahn
author_sort	Young-Min Kim
title	Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
title_short	Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
title_full	Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
title_fullStr	Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
title_full_unstemmed	Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children
title_sort	effects of exposure to indoor fine particulate matter on atopic dermatitis in children
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fd5034cf7efc417986199e08a7513a54
work_keys_str_mv	AT youngminkim effectsofexposuretoindoorfineparticulatematteronatopicdermatitisinchildren AT jihyunkim effectsofexposuretoindoorfineparticulatematteronatopicdermatitisinchildren AT seoungchulha effectsofexposuretoindoorfineparticulatematteronatopicdermatitisinchildren AT kangmoahn effectsofexposuretoindoorfineparticulatematteronatopicdermatitisinchildren
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Effects of Exposure to Indoor Fine Particulate Matter on Atopic Dermatitis in Children

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