Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis

Abstract Symptomatic overlap of depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) is a major diagnostic and therapeutic problem. Mania in medical history remains the only reliable distinguishing marker which is problematic given that episodes of depression compared to...

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Autores principales:	Martin Pastrnak, Eva Simkova, Tomas Novak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd50ec70d9944fbf9b787859f709a0b1
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spelling	oai:doaj.org-article:fd50ec70d9944fbf9b787859f709a0b12021-12-02T16:45:53ZInsula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis10.1038/s41598-021-96319-22045-2322https://doaj.org/article/fd50ec70d9944fbf9b787859f709a0b12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96319-2https://doaj.org/toc/2045-2322Abstract Symptomatic overlap of depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) is a major diagnostic and therapeutic problem. Mania in medical history remains the only reliable distinguishing marker which is problematic given that episodes of depression compared to episodes of mania are more frequent and predominantly present at the beginning of BD. Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive, task-free, and well-tolerated method that may provide diagnostic markers acquired from spontaneous neural activity. Previous rs-fMRI studies focused on differentiating BD from MDD depression were inconsistent in their findings due to low sample power, heterogeneity of compared samples, and diversity of analytical methods. This meta-analysis investigated resting-state activity differences in BD and MDD depression using activation likelihood estimation. PubMed, Web of Science, Scopus and Google Scholar databases were searched for whole-brain rs-fMRI studies which compared MDD and BD currently depressed patients between Jan 2000 and August 2020. Ten studies were included, representing 234 BD and 296 MDD patients. The meta-analysis found increased activity in the left insula and adjacent area in MDD compared to BD. The finding suggests that the insula is involved in neural activity patterns during resting-state that can be potentially used as a biomarker differentiating both disorders.Martin PastrnakEva SimkovaTomas NovakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Pastrnak Eva Simkova Tomas Novak Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
description	Abstract Symptomatic overlap of depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) is a major diagnostic and therapeutic problem. Mania in medical history remains the only reliable distinguishing marker which is problematic given that episodes of depression compared to episodes of mania are more frequent and predominantly present at the beginning of BD. Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive, task-free, and well-tolerated method that may provide diagnostic markers acquired from spontaneous neural activity. Previous rs-fMRI studies focused on differentiating BD from MDD depression were inconsistent in their findings due to low sample power, heterogeneity of compared samples, and diversity of analytical methods. This meta-analysis investigated resting-state activity differences in BD and MDD depression using activation likelihood estimation. PubMed, Web of Science, Scopus and Google Scholar databases were searched for whole-brain rs-fMRI studies which compared MDD and BD currently depressed patients between Jan 2000 and August 2020. Ten studies were included, representing 234 BD and 296 MDD patients. The meta-analysis found increased activity in the left insula and adjacent area in MDD compared to BD. The finding suggests that the insula is involved in neural activity patterns during resting-state that can be potentially used as a biomarker differentiating both disorders.
format	article
author	Martin Pastrnak Eva Simkova Tomas Novak
author_facet	Martin Pastrnak Eva Simkova Tomas Novak
author_sort	Martin Pastrnak
title	Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
title_short	Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
title_full	Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
title_fullStr	Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
title_full_unstemmed	Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
title_sort	insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd50ec70d9944fbf9b787859f709a0b1
work_keys_str_mv	AT martinpastrnak insulaactivityinrestingstatedifferentiatesbipolarfromunipolardepressionasystematicreviewandmetaanalysis AT evasimkova insulaactivityinrestingstatedifferentiatesbipolarfromunipolardepressionasystematicreviewandmetaanalysis AT tomasnovak insulaactivityinrestingstatedifferentiatesbipolarfromunipolardepressionasystematicreviewandmetaanalysis
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Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis

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