Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus

Рathogenesis of the chronic placental insufficiency is largely determined by the type of diabetes mellitus and the degree of its compensation. Trophic function failure of placenta changes its hormonal activity, formation of respiratory disorders and development of oxidative stress. The histological...

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Autores principales:	Tatyana G. Tral, Gulrukhsor Kh. Tolibova, Ekaterina V. Musina, Maria I. Yarmolinskaya
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	diabetes mellitus type 1 diabetes mellitus type 2 gestational diabetes mellitus chronic placental insufficiency Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/fd56f5ade4fb4f6dbda9829980dd478b
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spelling	oai:doaj.org-article:fd56f5ade4fb4f6dbda9829980dd478b2021-11-14T09:00:23ZMolecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus2072-03512072-037810.14341/DM10228https://doaj.org/article/fd56f5ade4fb4f6dbda9829980dd478b2020-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10228https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Рathogenesis of the chronic placental insufficiency is largely determined by the type of diabetes mellitus and the degree of its compensation. Trophic function failure of placenta changes its hormonal activity, formation of respiratory disorders and development of oxidative stress. The histological structure of placentas among patients with type 1 diabetes mellitus (T1D) is represented by reduced chorionic villi dimensions of all levels. Stromal edema and increased number of mesenchymal stromal cells are found in the stem and intermediate villi, and hypervascularisation and thickening of syncytiocapillary membranes are detected in terminal villi. In type 2 diabetes mellitus (T2D), the histological structure of the placenta may be represented as a premature maturation and abnormal immaturity of the villous tree with focal fibrosis of villi stroma, hypervascularisation of villi, abundance of syncytial nodules and infarction in the subchorial space. The peculiarity of the placenta structure in gestational diabetes mellitus is predominantly an intermediate immature type of development with angiogenesis abnormality. Angiogenesis processes failure and endothelial dysfunction in chorionic villi associated with hyperglycaemia change the permeability of cell membranes, transferring cells to anaerobic respiration. Metabolic imbalance in the placenta causes the development of diabetic micro-angiopathy in the fetal-placental complex, antenatal hypoxia and negative perinatal outcomes.Tatyana G. TralGulrukhsor Kh. TolibovaEkaterina V. MusinaMaria I. YarmolinskayaEndocrinology Research Centrearticlediabetes mellitus type 1diabetes mellitus type 2gestational diabetes mellituschronic placental insufficiencyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 2, Pp 185-191 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 1 diabetes mellitus type 2 gestational diabetes mellitus chronic placental insufficiency Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 1 diabetes mellitus type 2 gestational diabetes mellitus chronic placental insufficiency Nutritional diseases. Deficiency diseases RC620-627 Tatyana G. Tral Gulrukhsor Kh. Tolibova Ekaterina V. Musina Maria I. Yarmolinskaya Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
description	Рathogenesis of the chronic placental insufficiency is largely determined by the type of diabetes mellitus and the degree of its compensation. Trophic function failure of placenta changes its hormonal activity, formation of respiratory disorders and development of oxidative stress. The histological structure of placentas among patients with type 1 diabetes mellitus (T1D) is represented by reduced chorionic villi dimensions of all levels. Stromal edema and increased number of mesenchymal stromal cells are found in the stem and intermediate villi, and hypervascularisation and thickening of syncytiocapillary membranes are detected in terminal villi. In type 2 diabetes mellitus (T2D), the histological structure of the placenta may be represented as a premature maturation and abnormal immaturity of the villous tree with focal fibrosis of villi stroma, hypervascularisation of villi, abundance of syncytial nodules and infarction in the subchorial space. The peculiarity of the placenta structure in gestational diabetes mellitus is predominantly an intermediate immature type of development with angiogenesis abnormality. Angiogenesis processes failure and endothelial dysfunction in chorionic villi associated with hyperglycaemia change the permeability of cell membranes, transferring cells to anaerobic respiration. Metabolic imbalance in the placenta causes the development of diabetic micro-angiopathy in the fetal-placental complex, antenatal hypoxia and negative perinatal outcomes.
format	article
author	Tatyana G. Tral Gulrukhsor Kh. Tolibova Ekaterina V. Musina Maria I. Yarmolinskaya
author_facet	Tatyana G. Tral Gulrukhsor Kh. Tolibova Ekaterina V. Musina Maria I. Yarmolinskaya
author_sort	Tatyana G. Tral
title	Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
title_short	Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
title_full	Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
title_fullStr	Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
title_full_unstemmed	Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
title_sort	molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/fd56f5ade4fb4f6dbda9829980dd478b
work_keys_str_mv	AT tatyanagtral molecularandmorphologicalpeculiaritiesofchronicplacentalinsufficiencyformationcausedbydifferenttypesofdiabetesmellitus AT gulrukhsorkhtolibova molecularandmorphologicalpeculiaritiesofchronicplacentalinsufficiencyformationcausedbydifferenttypesofdiabetesmellitus AT ekaterinavmusina molecularandmorphologicalpeculiaritiesofchronicplacentalinsufficiencyformationcausedbydifferenttypesofdiabetesmellitus AT mariaiyarmolinskaya molecularandmorphologicalpeculiaritiesofchronicplacentalinsufficiencyformationcausedbydifferenttypesofdiabetesmellitus
_version_	1718429504630685696

Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus

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