Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation.
PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated wit...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fd576dbe8a454c828bfbff14fdf9730c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fd576dbe8a454c828bfbff14fdf9730c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fd576dbe8a454c828bfbff14fdf9730c2021-11-18T08:17:44ZProhibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation.1932-620310.1371/journal.pone.0098583https://doaj.org/article/fd576dbe8a454c828bfbff14fdf9730c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24879411/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.Mariana Ferreira LealPriscila Daniele Ramos CiriloTatiane Katsue Furuya MazzottiDanielle Queiroz CalcagnoFernanda WisnieskiSamia DemachkiMargarita Cortes MartinezPaulo Pimentel AssumpçãoRoger ChammasRommel Rodríguez BurbanoMarília Cardoso SmithPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98583 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Mariana Ferreira Leal Priscila Daniele Ramos Cirilo Tatiane Katsue Furuya Mazzotti Danielle Queiroz Calcagno Fernanda Wisnieski Samia Demachki Margarita Cortes Martinez Paulo Pimentel Assumpção Roger Chammas Rommel Rodríguez Burbano Marília Cardoso Smith Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| description |
PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation. |
| format |
article |
| author |
Mariana Ferreira Leal Priscila Daniele Ramos Cirilo Tatiane Katsue Furuya Mazzotti Danielle Queiroz Calcagno Fernanda Wisnieski Samia Demachki Margarita Cortes Martinez Paulo Pimentel Assumpção Roger Chammas Rommel Rodríguez Burbano Marília Cardoso Smith |
| author_facet |
Mariana Ferreira Leal Priscila Daniele Ramos Cirilo Tatiane Katsue Furuya Mazzotti Danielle Queiroz Calcagno Fernanda Wisnieski Samia Demachki Margarita Cortes Martinez Paulo Pimentel Assumpção Roger Chammas Rommel Rodríguez Burbano Marília Cardoso Smith |
| author_sort |
Mariana Ferreira Leal |
| title |
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| title_short |
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| title_full |
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| title_fullStr |
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| title_full_unstemmed |
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. |
| title_sort |
prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 c>t polymorphism and copy number variation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/fd576dbe8a454c828bfbff14fdf9730c |
| work_keys_str_mv |
AT marianaferreiraleal prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT prisciladanieleramoscirilo prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT tatianekatsuefuruyamazzotti prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT daniellequeirozcalcagno prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT fernandawisnieski prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT samiademachki prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT margaritacortesmartinez prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT paulopimentelassumpcao prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT rogerchammas prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT rommelrodriguezburbano prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation AT mariliacardososmith prohibitinexpressionderegulationingastriccancerisassociatedwiththe3untranslatedregion1630ctpolymorphismandcopynumbervariation |
| _version_ |
1718421961907896320 |