Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Deise Michele Tichota,1 Ana Catarina Silva,2,3 José Manuel Sousa Lobo,2 Maria Helena Amaral2 1Federal University of Rio Grande do Sul, Porto Alegre, 2Laboratory of Pharmaceutical Technology/Centre of Research in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, 3Faculty...

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Autores principales:	Tichota DM, Silva AC, Sousa Lobo JM, Amaral MH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fd57a7010bb04061b6af1a29bca79bde
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spelling	oai:doaj.org-article:fd57a7010bb04061b6af1a29bca79bde2021-12-02T02:42:32ZDesign, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration1178-2013https://doaj.org/article/fd57a7010bb04061b6af1a29bca79bde2014-08-01T00:00:00Zhttp://www.dovepress.com/design-characterization-and-clinical-evaluation-of-argan-oil-nanostruc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Deise Michele Tichota,1 Ana Catarina Silva,2,3 José Manuel Sousa Lobo,2 Maria Helena Amaral2 1Federal University of Rio Grande do Sul, Porto Alegre, 2Laboratory of Pharmaceutical Technology/Centre of Research in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, 3Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal Abstract: Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration). Keywords: argan oil, nanostructured lipid carriers, NLC, hydrogels, skin hydration Tichota DMSilva ACSousa Lobo JMAmaral MHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3855-3864 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tichota DM Silva AC Sousa Lobo JM Amaral MH Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
description	Deise Michele Tichota,1 Ana Catarina Silva,2,3 José Manuel Sousa Lobo,2 Maria Helena Amaral2 1Federal University of Rio Grande do Sul, Porto Alegre, 2Laboratory of Pharmaceutical Technology/Centre of Research in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, 3Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal Abstract: Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration). Keywords: argan oil, nanostructured lipid carriers, NLC, hydrogels, skin hydration
format	article
author	Tichota DM Silva AC Sousa Lobo JM Amaral MH
author_facet	Tichota DM Silva AC Sousa Lobo JM Amaral MH
author_sort	Tichota DM
title	Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
title_short	Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
title_full	Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
title_fullStr	Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
title_full_unstemmed	Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
title_sort	design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/fd57a7010bb04061b6af1a29bca79bde
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Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

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