Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4...

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Main Authors:	Simon Schroeder, Christin Mache, Hannah Kleine-Weber, Victor M. Corman, Doreen Muth, Anja Richter, Diana Fatykhova, Ziad A. Memish, Megan L. Stanifer, Steeve Boulant, Mitra Gultom, Ronald Dijkman, Stephan Eggeling, Andreas Hocke, Stefan Hippenstiel, Volker Thiel, Stefan Pöhlmann, Thorsten Wolff, Marcel A. Müller, Christian Drosten
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/fd5899e1e8ed4fc68c3c88e1bf84f1a6
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spelling	oai:doaj.org-article:fd5899e1e8ed4fc68c3c88e1bf84f1a62021-12-02T14:54:28ZFunctional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 510.1038/s41467-021-25519-12041-1723https://doaj.org/article/fd5899e1e8ed4fc68c3c88e1bf84f1a62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25519-1https://doaj.org/toc/2041-1723MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4 due to reduced activation of innate immune signaling.Simon SchroederChristin MacheHannah Kleine-WeberVictor M. CormanDoreen MuthAnja RichterDiana FatykhovaZiad A. MemishMegan L. StaniferSteeve BoulantMitra GultomRonald DijkmanStephan EggelingAndreas HockeStefan HippenstielVolker ThielStefan PöhlmannThorsten WolffMarcel A. MüllerChristian DrostenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Schroeder Christin Mache Hannah Kleine-Weber Victor M. Corman Doreen Muth Anja Richter Diana Fatykhova Ziad A. Memish Megan L. Stanifer Steeve Boulant Mitra Gultom Ronald Dijkman Stephan Eggeling Andreas Hocke Stefan Hippenstiel Volker Thiel Stefan Pöhlmann Thorsten Wolff Marcel A. Müller Christian Drosten Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
description	MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4 due to reduced activation of innate immune signaling.
format	article
author	Simon Schroeder Christin Mache Hannah Kleine-Weber Victor M. Corman Doreen Muth Anja Richter Diana Fatykhova Ziad A. Memish Megan L. Stanifer Steeve Boulant Mitra Gultom Ronald Dijkman Stephan Eggeling Andreas Hocke Stefan Hippenstiel Volker Thiel Stefan Pöhlmann Thorsten Wolff Marcel A. Müller Christian Drosten
author_facet	Simon Schroeder Christin Mache Hannah Kleine-Weber Victor M. Corman Doreen Muth Anja Richter Diana Fatykhova Ziad A. Memish Megan L. Stanifer Steeve Boulant Mitra Gultom Ronald Dijkman Stephan Eggeling Andreas Hocke Stefan Hippenstiel Volker Thiel Stefan Pöhlmann Thorsten Wolff Marcel A. Müller Christian Drosten
author_sort	Simon Schroeder
title	Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
title_short	Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
title_full	Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
title_fullStr	Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
title_full_unstemmed	Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
title_sort	functional comparison of mers-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd5899e1e8ed4fc68c3c88e1bf84f1a6
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

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