Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4...

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Main Authors: Simon Schroeder, Christin Mache, Hannah Kleine-Weber, Victor M. Corman, Doreen Muth, Anja Richter, Diana Fatykhova, Ziad A. Memish, Megan L. Stanifer, Steeve Boulant, Mitra Gultom, Ronald Dijkman, Stephan Eggeling, Andreas Hocke, Stefan Hippenstiel, Volker Thiel, Stefan Pöhlmann, Thorsten Wolff, Marcel A. Müller, Christian Drosten
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/fd5899e1e8ed4fc68c3c88e1bf84f1a6
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