Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study

Background: Numerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result. Nevertheless, it is well known that the cytotoxicity of bleomycin can be enhanced in vivo by 300 to 700-fold by electroporation. Objective and Me...

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Autores principales:	Paola Pasquali, Azael Freites-Martinez, Salvador Gonzalez, Enrico P. Spugnini, Alfonso Baldi
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2017
Materias:	warts bleomycin electroporation Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/fd5fb9b88d6a4850a4fadd7ad480890c
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spelling	oai:doaj.org-article:fd5fb9b88d6a4850a4fadd7ad480890c2021-11-17T08:30:38ZSuccessful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study10.5826/dpc.0703a042160-9381https://doaj.org/article/fd5fb9b88d6a4850a4fadd7ad480890c2017-08-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/292https://doaj.org/toc/2160-9381 Background: Numerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result. Nevertheless, it is well known that the cytotoxicity of bleomycin can be enhanced in vivo by 300 to 700-fold by electroporation. Objective and Methods: In this article, we present an interventional, one-center, prospective case series, clinical trial of the effectiveness of intralesional bleomycin combined with electroporation for the treatment of plantar warts, in comparison to the use of intralesional bleomycin alone. Results: The study’s cohort included 12 men and 10 women, with a mean age of 53.8 years. A total of 22 warts were treated. In dividing the patients in two groups (complete remission against all the others) and analyzing the different outcomes in the two arms of patients, a statistical significant difference was found (p=0.0015), proving a greater efficacy of the treatment with bleomycin combined with ECT as opposed to bleomycin alone. Electroporation was always well tolerated by the patients with no discomfort. Conclusions: This study serves as a basis for the application of novel protocols in the treatment of different benign and locally malignant skin lesion by means of electroporation. Paola PasqualiAzael Freites-MartinezSalvador GonzalezEnrico P. SpugniniAlfonso BaldiMattioli1885articlewartsbleomycinelectroporationDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 7, Iss 3 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	warts bleomycin electroporation Dermatology RL1-803
spellingShingle	warts bleomycin electroporation Dermatology RL1-803 Paola Pasquali Azael Freites-Martinez Salvador Gonzalez Enrico P. Spugnini Alfonso Baldi Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
description	Background: Numerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result. Nevertheless, it is well known that the cytotoxicity of bleomycin can be enhanced in vivo by 300 to 700-fold by electroporation. Objective and Methods: In this article, we present an interventional, one-center, prospective case series, clinical trial of the effectiveness of intralesional bleomycin combined with electroporation for the treatment of plantar warts, in comparison to the use of intralesional bleomycin alone. Results: The study’s cohort included 12 men and 10 women, with a mean age of 53.8 years. A total of 22 warts were treated. In dividing the patients in two groups (complete remission against all the others) and analyzing the different outcomes in the two arms of patients, a statistical significant difference was found (p=0.0015), proving a greater efficacy of the treatment with bleomycin combined with ECT as opposed to bleomycin alone. Electroporation was always well tolerated by the patients with no discomfort. Conclusions: This study serves as a basis for the application of novel protocols in the treatment of different benign and locally malignant skin lesion by means of electroporation.
format	article
author	Paola Pasquali Azael Freites-Martinez Salvador Gonzalez Enrico P. Spugnini Alfonso Baldi
author_facet	Paola Pasquali Azael Freites-Martinez Salvador Gonzalez Enrico P. Spugnini Alfonso Baldi
author_sort	Paola Pasquali
title	Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
title_short	Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
title_full	Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
title_fullStr	Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
title_full_unstemmed	Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
title_sort	successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study
publisher	Mattioli1885
publishDate	2017
url	https://doaj.org/article/fd5fb9b88d6a4850a4fadd7ad480890c
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Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study

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